Long-term outcomes of modern multidisciplinary management of sinonasal cancers: The M. D. Anderson experience.

Autor: Bahig H; Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.; Department of Radiation Oncology, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada., Ehab HY; Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA., Garden AS; Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA., Ng SP; Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.; Department of Radiation Oncology, Olivia Newton-John Cancer Centre, Austin Health, Melbourne, Victoria, Australia., Frank SJ; Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA., Nguyen T; Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA., Gunn GB; Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA., Rosenthal DI; Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA., Fuller CD; Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA., Ferrarotto R; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA., Bell D; Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA., Su S; Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA., Phan J; Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2023 Jul; Vol. 45 (7), pp. 1692-1703. Date of Electronic Publication: 2023 May 10.
DOI: 10.1002/hed.27381
Abstrakt: Purpose: To report long-term outcomes of modern radiotherapy for sinonasal cancers.
Methods and Materials: A retrospective analysis of patients with sinonasal tumors treated with intensity-modulated radiotherapy or proton therapy. Multivariate analysis was used to determine predictive variables of progression free survival (PFS) and overall survival (OS).
Results: Three hundred and eleven patients were included, with median follow-up of 75 months. The most common histologies were squamous cell (42%), adenoid cystic (15%), and sinonasal undifferentiated carcinoma (15%). Induction chemotherapy was administered to 47% of patients; 68% had adjuvant radiotherapy. Ten-year local control, regional control, distant metastasis free survival, PFS, and overall survival rates were 73%, 88%, 47%, 32%, and 51%, respectively. Age, non-nasal cavity tumor site, T3-4 stage, neck dissection, and radiation dose were predictive of PFS, while age, non-nasal cavity tumor site, T3-4 stage, positive margins, neck dissection, and use of neoadjuvant chemotherapy were predictive of OS. There was a 13% rate of late grade ≥3 toxicities.
Conclusion: This cohort of patients with sinonasal cancer treated with modern radiotherapy demonstrates favorable disease control rate and acceptable toxicity profile.
(© 2023 Wiley Periodicals LLC.)
Databáze: MEDLINE
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