| Autor: |
Idle JR, Mahgoub A, Angelo MM, Dring LG, Lancaster R, Smith RL |
| Jazyk: |
angličtina |
| Zdroj: |
British journal of clinical pharmacology [Br J Clin Pharmacol] 1979 Mar; Vol. 7 (3), pp. 257-66. |
| DOI: |
10.1111/j.1365-2125.1979.tb00930.x |
| Abstrakt: |
1 The synthesis of [14C]-debrisoquine hydrochloride and 4-hydroxy-debrisoquine sulphate is described. 2 The metabolic fate and excretion profile in both urine and faeces of 14C-labelled debrisoquine was studied in five healthy human subjects. 3 Investigations showed that the drug is well-absorbed after a single oral dose of 32 mg and quantitatively eliminated from the body within three days. 4 4-Hydroxy-debrisoquine is the major metabolite of debrisoquine, although significant amounts of 5-,6-, 7- and 8-hydroxy-debrisoquine are also formed. 5 Electron-capture gas chromatography is a useful method for measuring debrisoquine and its five hydroxylated metabolites in urine at the pg level. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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