Uptake and depuration of three common antibiotics in benthic organisms: Sea cucumber (Holothuria tubulosa), snakelocks anemone (Anemonia sulcata) and beadlet anemone (Actinia equina).

Autor: Gómez-Regalado MDC; Department of Analytical Chemistry, Sciences Faculty, University of Granada, E-18071, Granada, Spain., Martín J; Department of Analytical Chemistry, Escuela Politécnica Superior, University of Seville, C/ Virgen de África 7, E-41011, Seville, Spain. Electronic address: jbueno@us.es., Hidalgo F; Department of Zoology, Sciences Faculty, University of Granada, E-18071, Granada, Spain., Santos JL; Department of Analytical Chemistry, Escuela Politécnica Superior, University of Seville, C/ Virgen de África 7, E-41011, Seville, Spain., Aparicio I; Department of Analytical Chemistry, Escuela Politécnica Superior, University of Seville, C/ Virgen de África 7, E-41011, Seville, Spain., Alonso E; Department of Analytical Chemistry, Escuela Politécnica Superior, University of Seville, C/ Virgen de África 7, E-41011, Seville, Spain., Zafra-Gómez A; Department of Analytical Chemistry, Sciences Faculty, University of Granada, E-18071, Granada, Spain; Instituto de Investigación Biosanitaria, Ibs.Granada, E-18016, Granada, Spain; Institute of Nutrition and Food Technology, INYTA, University of Granada, Spain. Electronic address: azafra@ugr.es.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2023 Sep 01; Vol. 232, pp. 116082. Date of Electronic Publication: 2023 May 08.
DOI: 10.1016/j.envres.2023.116082
Abstrakt: Antibiotics are widely used drugs in human and veterinary medicine, which has attracted great attention in relation to the development of bacterial resistance, currently a problem of great concern for governments and states, as it is related to the resurgence of infectious diseases already eradicated. Understanding the bioaccumulation of antibiotics in aquatic organisms is an important key to understanding their risk assessment. The present study was designed to study the bioaccumulation of target antibiotics in relevant organisms inhabiting benthic marine environments. The uptake and elimination of ciprofloxacin (CIP), sulfamethoxazole (SMX) and trimethoprim (TMP) were investigated in sea cucumbers (Holothuria tubulosa), snakelock anemone (Anemonia sulcata) and beadlet anemone (Actinia equina) under controlled laboratory conditions. The results show that antibiotics have a particular trend over time during all periods of absorption and depuration. The tissue distribution of antibiotics in sea cucumber is strongly influenced by the structure of the compounds, while CIP is concentrated in the body wall; TMP is concentrated in the digestive tract. Two different approaches were used to estimate bioconcentration factors (BCFs) in different animal models, based on toxicokinetic data and measured steady-state concentrations. The BCF ranges were 456-2731 L/kg, 6-511 L/kg and 9-100 L/kg for TMP, CIP and SMX, respectively. The estimated BCF values obtained classify TMP as cumulative in A. equina and H. tubulosa, underlining the potential bioconcentration in these marine organisms. A correlation was observed between the BCFs of the target antibiotics and the octanol-water distribution coefficient (D ow ) (r 2 > 0.7). The animal-specific BCF followed the order of beadlet anemone > sea cucumber > snakelock anemone.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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