The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years' experience of association studies to understand the genetic architecture of pancreatic cancer.

Autor: Campa D; Unit of Genetic, Department of Biology, University of Pisa, Pisa, Italy. Electronic address: daniele.campa@unipi.it., Gentiluomo M; Unit of Genetic, Department of Biology, University of Pisa, Pisa, Italy., Stein A; Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Aoki MN; Laboratory for Applied Science and Technology in Health, Carlos Chagas Institute, Oswaldo Cruz Foundation (Fiocruz), Curitiba, Brazil., Oliverius M; Department of Surgery, University Hospital Kralovske Vinohrady, Third Faculty of Medicine, Charles University, Prague, Czech Republic., Vodičková L; Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, 1st Faculty of Medicine Charles University and General University Hospital in Prague, Prague, Czech Republic; Biomedical Centre, Faculty of Medicine in Pilsen Charles University, Pilsen, Czech Republic., Jamroziak K; Department of Hematology, Transplantation and Internal Medicine, Medical University of Warsaw, Warsaw, Poland., Theodoropoulos G; First Department of Propaedeutic Surgery, Hippocration General Hospital, National and Kapodistrian University of Athens, Athens, Greece., Pasquali C; Dept. of Surgery, Oncology and Gastroenterology, University of Padova Chirurgia Generale 3, Padova, Italy., Greenhalf W; Liverpool Experimental Cancer Medicine Centre, University of Liverpool, Liverpool, United Kingdom., Arcidiacono PG; Pancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientic Institute, Milan, Italy., Uzunoglu F; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Pezzilli R; Potenza Medica County Association, Potenza, Italy., Luchini C; Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, Italy., Puzzono M; Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy., Loos M; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany., Giaccherini M; Unit of Genetic, Department of Biology, University of Pisa, Pisa, Italy., Katzke V; Division of Cancer Epidemiology C020, German Cancer Research Center (DKFZ), Heidelberg, Germany., Mambrini A; Oncological Department Massa Carrara, Azienda USL Toscana Nord Ovest, Carrara, Italy., Kiudeliene E; Institute for Digestive Research and Gastroenterology Department, Lithuanian University of Health Sciences, Kaunas, Lithuania., Federico KE; Division of General and Transplant Surgery, Pisa University Hospital, Pisa, Italy., Johansen J; Departments of Oncology and Medicine, Copenhagen University Hospital, Herlev, Denmark., Hussein T; Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary; Center for Translational Medicine, Semmelweis University, Budapest, Hungary., Mohelnikova-Duchonova B; Department of Oncology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic., van Eijck CHJ; Department of Surgery, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Farinella R; Unit of Genetic, Department of Biology, University of Pisa, Pisa, Italy., Pérez JS; Genomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Complejo Hospitales Universitarios de Granada, Universidad de Granada, Granada, Spain; Department of Immunology, University of Granada, Granada, Spain., Lovecek M; Department of Surgery I, University Hospital Olomouc, Olomouc, Czech Republic., Büchler MW; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany., Hlavac V; Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic., Izbicki JR; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hackert T; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany., Chammas R; Center for Translational Research in Oncology (LIM24), Departamento de Radiologia e Oncologia, Instituto Do Câncer Do Estado de São Paulo (ICESP), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, Brazil., Zerbi A; Pancreatic Unit, IRCCS Humanitas Research Hospital, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Lawlor R; ARC-Net Research Center, Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Verona, Italy., Felici A; Unit of Genetic, Department of Biology, University of Pisa, Pisa, Italy., Götz M; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Capurso G; Pancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy; Digestive and Liver Disease Unit, Sant' Andrea Hospital, Rome, Italy., Ginocchi L; Oncological Department Massa Carrara, Azienda USL Toscana Nord Ovest, Carrara, Italy., Gazouli M; Laboratory of Biology, Department of Basic Medical Sciences, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Kupcinskas J; Institute for Digestive Research and Gastroenterology Department, Lithuanian University of Health Sciences, Kaunas, Lithuania., Cavestro GM; Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy., Vodicka P; Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, 1st Faculty of Medicine Charles University and General University Hospital in Prague, Prague, Czech Republic; Biomedical Centre, Faculty of Medicine in Pilsen Charles University, Pilsen, Czech Republic., Moz S; Azienda Ospedale-Università di Padova Medicina di Laboratorio, Padova, Italy., Neoptolemos JP; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany., Kunovsky L; Department of Surgery, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Gastroenterology and Digestive Endoscopy, Masaryk Memorial Cancer Institute, Brno, Czech Republic; 2nd Department of Internal Medicine - Gastroenterology and Geriatrics, University Hospital Olomouc, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic., Bojesen SE; Departments of Oncology and Medicine, Copenhagen University Hospital, Herlev, Denmark., Carrara S; Endoscopic Unit, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Milan, Italy., Gioffreda D; Division of Gastroenterology and Research Laboratory, Fondazione IRCCS 'Casa Sollievo della Sofferenza' Hospital, San Giovanni Rotondo, Italy., Morkunas E; Institute for Digestive Research and Gastroenterology Department, Lithuanian University of Health Sciences, Kaunas, Lithuania., Abian O; Instituto BIFI-Universidad de Zaragoza, Zaragoza, Spain., Bunduc S; Center for Translational Medicine, Semmelweis University, Budapest, Hungary; Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Center for Digestive Diseases and Liver Transplant, Fundeni Clinical Insitute, Bucharest, Romania., Basso D; Dept. of Medicine, University of Padova Medicina di Laboratorio, Padova, Italy., Boggi U; Division of General and Transplant Surgery, Pisa University Hospital, Pisa, Italy., Wlodarczyk B; Dept of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland., Szentesi A; Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary., Vanella G; Pancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy; Digestive and Liver Disease Unit, Sant' Andrea Hospital, Rome, Italy., Chen I; Departments of Oncology and Medicine, Copenhagen University Hospital, Herlev, Denmark., Bijlsma MF; Center for Experimental and Molecular Medicine, Laboratory of Experimental Oncology and Radiobiology, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands; Oncode Institute, Amsterdam, the Netherlands; Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, the Netherlands., Kiudelis V; Institute for Digestive Research and Gastroenterology Department, Lithuanian University of Health Sciences, Kaunas, Lithuania., Landi S; Unit of Genetic, Department of Biology, University of Pisa, Pisa, Italy., Schöttker B; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Corradi C; Unit of Genetic, Department of Biology, University of Pisa, Pisa, Italy., Giese N; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany., Kaaks R; Division of Cancer Epidemiology C020, German Cancer Research Center (DKFZ), Heidelberg, Germany., Peduzzi G; Unit of Genetic, Department of Biology, University of Pisa, Pisa, Italy., Hegyi P; Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary; Center for Translational Medicine, Semmelweis University, Budapest, Hungary; Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary; Translational Pancreatology Research Group, Interdisciplinary Centre of Excellence for Research Development and Innovation University of Szeged, Szeged, Hungary., Morelli L; General Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy., Furbetta N; General Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy., Soucek P; Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic., Latiano A; Division of Gastroenterology and Research Laboratory, Fondazione IRCCS 'Casa Sollievo della Sofferenza' Hospital, San Giovanni Rotondo, Italy., Talar-Wojnarowska R; Dept of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland., Lindgaard SC; Departments of Oncology and Medicine, Copenhagen University Hospital, Herlev, Denmark., Dijk F; Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, the Netherlands; Department of Pathology, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands., Milanetto AC; Dept. of Surgery, Oncology and Gastroenterology, University of Padova Chirurgia Generale 3, Padova, Italy., Tavano F; Division of Gastroenterology and Research Laboratory, Fondazione IRCCS 'Casa Sollievo della Sofferenza' Hospital, San Giovanni Rotondo, Italy., Cervena K; Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, 1st Faculty of Medicine Charles University and General University Hospital in Prague, Prague, Czech Republic., Erőss B; Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary; Center for Translational Medicine, Semmelweis University, Budapest, Hungary; Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary., Testoni SG; Pancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientic Institute, Milan, Italy., Verhagen-Oldenampsen JHE; Department of Pulmonary diseases, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Małecka-Wojciesko E; Dept of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland., Costello E; Liverpool Experimental Cancer Medicine Centre, University of Liverpool, Liverpool, United Kingdom., Salvia R; Department of Surgery, The Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy., Maiello E; Department of Oncology, Fondazione IRCCS 'Casa Sollievo della Sofferenza' Hospital, San Giovanni Rotondo, Italy., Ermini S; Meyer Children's Hospital IRCCS, Florence, Italy., Sperti C; Dept. of Surgery, Oncology and Gastroenterology, University of Padova Chirurgia Generale 1, Padova, Italy., Holleczek B; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Saarland Cancer Registry, Saarbrücken, Germany., Perri F; Division of Gastroenterology and Research Laboratory, Fondazione IRCCS 'Casa Sollievo della Sofferenza' Hospital, San Giovanni Rotondo, Italy., Skieceviciene J; Institute for Digestive Research and Gastroenterology Department, Lithuanian University of Health Sciences, Kaunas, Lithuania., Archibugi L; Pancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy; Digestive and Liver Disease Unit, Sant' Andrea Hospital, Rome, Italy., Lucchesi M; Oncological Department Massa Carrara, Azienda USL Toscana Nord Ovest, Carrara, Italy., Rizzato C; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy., Canzian F; Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: f.canzian@dkfz.de.
Jazyk: angličtina
Zdroj: Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2023 Jun; Vol. 186, pp. 104020. Date of Electronic Publication: 2023 May 08.
DOI: 10.1016/j.critrevonc.2023.104020
Abstrakt: Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of pancreatic cancer poses significant hurdles for research aimed at increasing our knowledge of the genetic mechanisms contributing to the disease. Additionally, the inability to adequately power research questions prevents small monocentric studies from being successful. Several consortia have been established to pursue a better understanding of the genetic architecture of pancreatic cancers. The Pancreatic disease research (PANDoRA) consortium is the largest in Europe. PANDoRA is spread across 12 European countries, Brazil and Japan, bringing together 29 basic and clinical research groups. In the last ten years, PANDoRA has contributed to the discovery of 25 susceptibility loci, a feat that will be instrumental in stratifying the population by risk and optimizing preventive strategies.
Competing Interests: Declaration of Competing Interest MFB has received research funding from Celgene, Frame Therapeutics, and Lead Pharma, and has acted as a consultant to Servier.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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