Role of condensates in modulating DNA repair pathways and its implication for chemoresistance.

Autor:	Dall'Agnese G; Laboratory of Molecular Biology and DNA repair, Department of Medicine, University of Udine, Udine, Italy; Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA., Dall'Agnese A; Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA., Banani SF; Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Codrich M; Laboratory of Molecular Biology and DNA repair, Department of Medicine, University of Udine, Udine, Italy., Malfatti MC; Laboratory of Molecular Biology and DNA repair, Department of Medicine, University of Udine, Udine, Italy., Antoniali G; Laboratory of Molecular Biology and DNA repair, Department of Medicine, University of Udine, Udine, Italy., Tell G; Laboratory of Molecular Biology and DNA repair, Department of Medicine, University of Udine, Udine, Italy. Electronic address: gianluca.tell@uniud.it.
Jazyk:	angličtina
Zdroj:	The Journal of biological chemistry [J Biol Chem] 2023 Jun; Vol. 299 (6), pp. 104800. Date of Electronic Publication: 2023 May 09.
DOI:	10.1016/j.jbc.2023.104800
Abstrakt:	For cells, it is important to repair DNA damage, such as double-strand and single-strand DNA breaks, because unrepaired DNA can compromise genetic integrity, potentially leading to cell death or cancer. Cells have multiple DNA damage repair pathways that have been the subject of detailed genetic, biochemical, and structural studies. Recently, the scientific community has started to gain evidence that the repair of DNA double-strand breaks may occur within biomolecular condensates and that condensates may also contribute to DNA damage through concentrating genotoxic agents used to treat various cancers. Here, we summarize key features of biomolecular condensates and note where they have been implicated in the repair of DNA double-strand breaks. We also describe evidence suggesting that condensates may be involved in the repair of other types of DNA damage, including single-strand DNA breaks, nucleotide modifications (e.g., mismatch and oxidized bases), and bulky lesions, among others. Finally, we discuss old and new mysteries that could now be addressed considering the properties of condensates, including chemoresistance mechanisms. Competing Interests: Conflict of interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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