Metabolic syndrome and cognitive deficits in the Greek cohort of Epirus Health Study.

Autor: Koutsonida M; Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece., Koskeridis F; Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece., Markozannes G; Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece., Kanellopoulou A; Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece., Mousas A; Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece., Ntotsikas E; Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece., Ioannidis P; B' Department of Neurology, AHEPA University Hospital of Thessaloniki, Aristotle University of Thessaloniki, Thessaloniki, Greece., Aretouli E; Department of Psychology, School of Social Sciences, University of Ioannina, Ioannina, Greece. earetouli@uoi.gr., Tsilidis KK; Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece. k.tsilidis@imperial.ac.uk.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom. k.tsilidis@imperial.ac.uk.
Jazyk: angličtina
Zdroj: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2023 Oct; Vol. 44 (10), pp. 3523-3533. Date of Electronic Publication: 2023 May 10.
DOI: 10.1007/s10072-023-06835-4
Abstrakt: Background: Metabolic syndrome is considered an important risk factor for cognitive decline and dementia. However, the evidence in middle-aged individuals is still conflicting. The aim of the study was to explore the association between metabolic syndrome and its individual components with cognitive function and to investigate possible interaction between sex, age and genetic predisposition for metabolic syndrome and Alzheimer's disease in a middle-aged Greek cohort.
Methods: A total of 2,077 healthy adults (mean age: 46.7 years) were included in the primary cross-sectional analysis and 305 of them in secondary prospective analyses. Metabolic syndrome was defined by the revised National Cholesterol Education-Adult Treatment Panel III and the International Diabetes Federation criteria. Cognitive function was measured primarily with the Trail Making, Verbal fluency and Logical Memory test, and in secondary prospective analyses with online versions of Posner cueing task, an emotional recognition task, Corsi block-tapping task and Stroop task.
Results: Multivariable linear regressions showed an association of metabolic syndrome with lower performance in attention (β=1.62 seconds, 95% CI=0.20, 3.04) and memory (β=-0.62 words, 95% CI=-1.19, -0.05) that could be driven by associations with elevated fasting glucose and abdominal obesity. Similar associations were observed in the secondary prospective analyses.
Conclusion: In summary, metabolic syndrome was associated with cognitive deficits in domains related with the cognitive profile of vascular cognitive impairment.
(© 2023. The Author(s).)
Databáze: MEDLINE
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