Effect of heat stress on TNF-α, TNFRI and TNFRII expression in BLV infected dairy cattle.

Autor: Lendez PA; Faculty of Veterinary Sciences, Universidad Nacional Del Centro De la Provincia de Buenos Aires (UNCPBA), Tandil, Veterinary Research Center (CIVETAN), CONICET-CICPBA, Arroyo Seco S/N, Campus Universitario, Tandil, 7000, Argentina., Martínez Cuesta L; Faculty of Veterinary Sciences, Universidad Nacional Del Centro De la Provincia de Buenos Aires (UNCPBA), Tandil, Veterinary Research Center (CIVETAN), CONICET-CICPBA, Arroyo Seco S/N, Campus Universitario, Tandil, 7000, Argentina., Nieto Farías MV; Faculty of Veterinary Sciences, Universidad Nacional Del Centro De la Provincia de Buenos Aires (UNCPBA), Tandil, Veterinary Research Center (CIVETAN), CONICET-CICPBA, Arroyo Seco S/N, Campus Universitario, Tandil, 7000, Argentina., Vater AA; Escuela de Educación Secundaria Agraria N°1 'DR, RAMON SANTAMARINA', Pje La Porteña, Ruta Pcial N, 30 KM 122.5, Tandil, Argentina., Ghezzi MD; Faculty of Veterinary Sciences, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Arroyo Seco S/N, Campus Universitario, Tandil, 7000, Argentina., Mota-Rojas D; Stress Physiology and Farm Animal Welfare, Departamento de Producción Agrícola y Animal, Universidad Autónoma Metropolitana (UAM), Ciudad de México, Mexico., Dolcini GL; Faculty of Veterinary Sciences, Universidad Nacional Del Centro De la Provincia de Buenos Aires (UNCPBA), Tandil, Veterinary Research Center (CIVETAN), CONICET-CICPBA, Arroyo Seco S/N, Campus Universitario, Tandil, 7000, Argentina., Ceriani MC; Faculty of Veterinary Sciences, Universidad Nacional Del Centro De la Provincia de Buenos Aires (UNCPBA), Tandil, Veterinary Research Center (CIVETAN), CONICET-CICPBA, Arroyo Seco S/N, Campus Universitario, Tandil, 7000, Argentina. Electronic address: cceriani@vet.unicen.edu.ar.
Jazyk: angličtina
Zdroj: Journal of thermal biology [J Therm Biol] 2023 Apr 26; Vol. 114, pp. 103568. Date of Electronic Publication: 2023 Apr 26.
DOI: 10.1016/j.jtherbio.2023.103568
Abstrakt: High temperatures for extended periods, which do not allow animals to recover from heat stress, affect in particular those BLV-infected animals that carry a high proviral load. For this study, animals were discriminated between BLV (+) and BLV (-), and those belonging to the first group, were classified based on their proviral load. The expression of the inflammatory cytokine TNF-α and its receptors, which play an important role in disease progression, were quantified by qPCR in two different seasons. During the summer, average temperature was 19.8 °C, maximums higher than 30 °C were frequent. Instead, during the autumn, the average temperature was 12.63 °C, and temperatures never exceeded 27 °C. During this season, almost no periods of temperatures exceeded the comfort limit. Our results revealed that the expression levels of TNF-α and its receptors were downregulated in animals with high proviral load. This fact could affect their antiviral response and predispose to viral dissemination; over time, animals with a poorer immune system are prone to acquiring opportunistic diseases. Conversely, animals with LPL maintained their expression profile, with behavior comparable to non-infected animals. These findings should be considered by producers and researchers, given the problems that global warming is causing lately to the planet.
Competing Interests: Declaration of competing interest The authors report no declarations of interest.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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