Cardiac Outcome of Children With SARS-CoV-2 Related Multisystem Inflammatory Syndrome.

Autor: Ghodsi AR; Department of Pediatrics, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran., Malek A; Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Siroosbakht S; Department of Pediatrics, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran., Aminian A; Department of Pediatrics, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran., Dormanesh B; Department of Pediatrics, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran., Azarfar A; Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Zoshk MY; Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Correspondence to: Dr MY Zoshk, Department of Pediatrics, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran. dr.yousefi.md@gmail.com.
Jazyk: angličtina
Zdroj: Indian pediatrics [Indian Pediatr] 2023 May 15; Vol. 60 (5), pp. 381-384. Date of Electronic Publication: 2023 Mar 20.
Abstrakt: Objective: To study the cardiac outcomes of patients with multisystem inflammatory syndrome in children (MIS-C) after 6-month of diagnosis.
Methods: This review of hospital records was conducted on MIS-C patients (aged <21 year) who completed a six-month follow up. The baseline demographic, clinical, laboratory, and treatment characteristics during the acute phase, and echocardiographic findings during follow-up were collected.
Results: 116 patients (61.2% male, median age 7 years) with MIS-C were included in the study. At the time of admission, cardiac abnormalities were present in 70.7% of MIS-C patients, and the most common cardiac abnormalities were valve failure (50.9%), followed by ventricular dysfunction (39.7%), and pericardial effusion (23.3%). Six month after diagnosis, cardiac abnormalities were found in 10.3% of patients, and patients had lower rates of ventricular dysfunction (P<0.001), valve failure (P<0.001), pericardial effusion (P<0.001), and coronary involvement (P<0.001) as composed to the baseline. Intravenous immunoglobulin (IVIG) and steroid treatment significantly reduced the odds of occurrence of ventricular dysfunction (P=0.002), valve failure (P=0.004), and low ejection fraction (P=0.002) in comparison to IVIG treatment.
Conclusion: While most MIS-C patients had abnormal echocardiographic findings at admission, only 10.3% of patients had cardiac abnormalities during follow up.
Databáze: MEDLINE
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