Evaluation of the Effectiveness of Systemic Therapy of Spinal Cord Injury of Moderate Severity with Human Umbilical Cord Placental Blood Mononuclear Cells Using Indicators of Dispersion of Articular Angles in the Swimming Test.

Autor: Bazanovich SA; Laboratory of Human Stem Cells, E. I. Chazov National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia., Ryabov SI; Laboratory of Human Stem Cells, E. I. Chazov National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia., Zvyagintseva MA; Laboratory of Human Stem Cells, E. I. Chazov National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia., Yadgarov MY; Laboratory of Human Stem Cells, E. I. Chazov National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia., Talypov AE; Scientific Department of Emergency Surgery, N. V. Sklifosovsky Research Institute for Emergency Medicine, Moscow, Russia., Grin' AA; Scientific Department of Emergency Surgery, N. V. Sklifosovsky Research Institute for Emergency Medicine, Moscow, Russia., Smirnov VA; Scientific Department of Emergency Surgery, N. V. Sklifosovsky Research Institute for Emergency Medicine, Moscow, Russia. vla_smirnov@mail.ru.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2023 Apr; Vol. 174 (6), pp. 784-789. Date of Electronic Publication: 2023 May 09.
DOI: 10.1007/s10517-023-05790-6
Abstrakt: Female Sprague-Dawley rats were used as models of moderate contusion spinal cord injury to evaluate the efficiency of single systemic (intravenous) infusion of human mononuclear cord blood cells for restoration of the motor function of hind limbs. The dynamics of recovery of hind limb motor function was assessed using a specially designed method based on calculation of selective dispersion and amplitude-dependent dispersion of hind limbs joint angles measured in the swimming test. The obtained data suggest that systemic application of human mononuclear cord blood cells significantly (p<0.05) promoted recovery of hind limb motor function in the animal models of contusion spinal cord injury of moderate severity in comparison with control animals (without cell therapy).
(© 2023. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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