Effect of stress hyperglycaemia on acute kidney injury in non-diabetic critically ill patients?

Autor: Ülger P; Department of Nephrology, University Duisburg-Essen, Essen, Germany., Yildiz E; Department of Nephrology, University Duisburg-Essen, Essen, Germany., Tyczynski B; Department of Nephrology, University Duisburg-Essen, Essen, Germany., Findeisen H; Department of Medicine, Rotes Kreuz Krankenhaus, St. Pauli Deich 24, 28199, Bremen, Germany., Kribben A; Department of Nephrology, University Duisburg-Essen, Essen, Germany., Janssen OE; Endokrinologikum, and Asklepios Medical School, Hamburg, Germany.; Subsidiary of the Semmelweis University, Budapest, Hungary., Herget-Rosenthal S; Department of Nephrology, University Duisburg-Essen, Essen, Germany. herget-rosenthal.s@roteskreuzkrankenhaus.de.; Department of Medicine, Rotes Kreuz Krankenhaus, St. Pauli Deich 24, 28199, Bremen, Germany. herget-rosenthal.s@roteskreuzkrankenhaus.de.
Jazyk: angličtina
Zdroj: International urology and nephrology [Int Urol Nephrol] 2023 Dec; Vol. 55 (12), pp. 3253-3259. Date of Electronic Publication: 2023 May 09.
DOI: 10.1007/s11255-023-03612-2
Abstrakt: Background: Stress hyperglycaemia (SH) and acute kidney injury (AKI) occur frequently in critically ill patients, and particularly non-diabetics are associated with adverse outcome. Data is scarce on the effect of SH on AKI. We assessed whether SH (i) preceded AKI, (ii) was a risk factor of subsequent AKI, and (iii) how SH and tubular injury interacted in AKI development in critically ill, non-diabetics.
Methods: Case-control study of 82 patients each with and without SH matched by propensity score for multiple demographic characteristics. AKI was defined by KDIGO criteria, SH either as blood glucose (BG) > 140 mg/dl (BG 140 ), > 200 mg/dl (BG 200 ), or stress hyperglycemia rate (SHR) ≥ 1.47 (SHR 1.47 ) as measured 2 days before AKI. Urinary cystatin C and neutrophil gelatinase-associated lipocalin (NGAL) indicated tubular injury.
Results: In AKI, SH rates were frequent using all 3 definitions applied, but highest when BG 140 was applied. SH by all 3 definitions was consistently associated with AKI. This was independent of established risk factors of AKI such as sepsis and shock. Increments of BG, urinary NGAL or cystatin C, and its products, were independently associated with the likelihood of subsequent AKI, demonstrating their reciprocal potentiating effects on AKI development.
Conclusions: SH is frequent in critically ill, non-diabetics with AKI. SH was identified as an independent risk factor of AKI. Higher BG combined with tubular injury may potentiate their adverse effects on AKI.
(© 2023. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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