| Autor: |
Susick RL Jr, Abrams GD, Zurawski CA, Zannoni VG |
| Jazyk: |
angličtina |
| Zdroj: |
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 1986 Jun 30; Vol. 84 (2), pp. 329-35. |
| DOI: |
10.1016/0041-008x(86)90141-9 |
| Abstrakt: |
Protection against the toxic effects of chronic alcohol consumption was observed in male guinea pigs maintained on a high-ascorbic-acid diet (vitamin C-deficient chow plus 2.0 mg ascorbic acid/ml drinking water) as compared to animals on a low-ascorbic-acid diet (vitamin C-deficient chow and from 0.025 to 0.050 mg ascorbic acid/ml drinking water). Alcohol was orally administered to the guinea pigs at a dose of 2.5 g/kg for up to 14 weeks. Levels of serum aspartate aminotransferase and serum alanine aminotransferase were significantly elevated in animals on the low-ascorbic-acid diet that received alcohol, 120 and 250%, respectively. In contrast, in animals on the high-ascorbic-acid diet that received alcohol, levels of alanine aminotransferase were not significantly elevated and levels of aspartate aminotransferase were elevated 50%. In addition, some of the animals on the low-ascorbic-acid diet that received alcohol for 12 to 14 weeks developed hepatic steatosis and necrosis, whereas none of the animals on the high-ascorbic-acid diet that received alcohol for the same length of time manifested these changes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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