Cannabidiol for musculoskeletal regenerative medicine.

Autor:	Marques Azzini GO; Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, Brazil., Marques Azzini VO; Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, Brazil., Santos GS; Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, Brazil., Visoni S; Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, Brazil., Fusco MA; Hospital Naval Marcílio Dias, Rio de Janeiro 20725-090, Brazil., Beker NS; Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, Brazil., Mahmood A; University Hospitals Birmingham, Birmingham B15 2PR, UK., Bizinotto Lana JV; Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, Brazil.; Medical Specialties School Centre, Centro Universitário Max Planck, Indaiatuba, 13343-060, Brazil., Jeyaraman M; Department of Orthopaedics, A.C.S. Medical College and Hospital, Dr.M.G.R. Educational and Research Institute, Chennai 600056, India.; Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida 201310, India.; South Texas Orthopaedic Research Institute (STORI Inc.), Laredo, TX 78045, USA.; Indian Stem Cell Study Group (ISCSG) Association, Lucknow 226010, India., Nallakumarasamy A; Indian Stem Cell Study Group (ISCSG) Association, Lucknow 226010, India.; Department of Orthopaedics, All India Institute of Medical Sciences, Bhubaneswar 751019, India., Jeyaraman N; Indian Stem Cell Study Group (ISCSG) Association, Lucknow 226010, India.; Department of Orthopaedics, Atlas Hospitals, Tiruchirappalli 620002, India., da Fonseca LF; Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, Brazil.; Universidade Federal de São Paulo (UNIFESP), São Paulo, 04021-001, Brazil., Luz Arab MG; Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, Brazil.; Saúde Máxima (SAMAX), São Paulo, 01239-040, Brazil., Vicente R; Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, Brazil.; Ultra Sports Science, São Paulo, Brazil., Rajendran RL; Department of Nuclear Medicine, School of Medicine, Kyungpook National University Hospital, Kyungpook National University, Daegu 41944, Republic of Korea., Gangadaran P; Department of Nuclear Medicine, School of Medicine, Kyungpook National University Hospital, Kyungpook National University, Daegu 41944, Republic of Korea.; BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Science, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea., Ahn BC; Department of Nuclear Medicine, School of Medicine, Kyungpook National University Hospital, Kyungpook National University, Daegu 41944, Republic of Korea.; BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Science, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea., Duarte Lana JFS; Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, Brazil.
Jazyk:	angličtina
Zdroj:	Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2023 May; Vol. 248 (5), pp. 445-455. Date of Electronic Publication: 2023 May 09.
DOI:	10.1177/15353702231162086
Abstrakt:	Chronic musculoskeletal (MSK) pain is one of the most prevalent causes, which lead patients to a physician's office. The most common disorders affecting MSK structures are osteoarthritis, rheumatoid arthritis, back pain, and myofascial pain syndrome, which are all responsible for major pain and physical disability. Although there are many known management strategies currently in practice, phytotherapeutic compounds have recently begun to rise in the medical community, especially cannabidiol (CBD). This natural, non-intoxicating molecule derived from the cannabis plant has shown interesting results in many preclinical studies and some clinical settings. CBD plays vital roles in human health that go well beyond the classic immunomodulatory, anti-inflammatory, and antinociceptive properties. Recent studies demonstrated that CBD also improves cell proliferation and migration, especially in mesenchymal stem cells (MSCs). The foremost objective of this review article is to discuss the therapeutic potential of CBD in the context of MSK regenerative medicine. Numerous studies listed in the literature indicate that CBD possesses a significant capacity to modulate mammalian tissue to attenuate and reverse the notorious hallmarks of chronic musculoskeletal disorders (MSDs). The most of the research included in this review report common findings like immunomodulation and stimulation of cell activity associated with tissue regeneration, especially in human MSCs. CBD is considered safe and well tolerated as no serious adverse effects were reported. CBD promotes many positive effects which can manage detrimental alterations brought on by chronic MSDs. Since the application of CBD for MSK health is still undergoing expansion, additional randomized clinical trials are warranted to further clarify its efficacy and to understand its cellular mechanisms.
Databáze:	MEDLINE
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