| Autor: |
Fernandes FHA; School of Pharmacy, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil.; UNIFACISA Centro Universitário, Campina Grande, Paraíba, Brazil., Soares SDS; Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany., Bekbolatova E; School of Pharmacy, JSC National Medical University, Almaty, Kazakhstan., Boylan F; School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Salgado HRN; School of Pharmacy, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil. |
| Abstrakt: |
Spondias dulcis Parkinson have been used in traditional medicine in Asia, Oceania, and South America, for different diseases conditions and as a functional food. The scientific literature described as different potential pharmacology such as antioxidant, anti-inflammatory, antimicrobial, thrombolytic and enzymatic inhibitor. This study aimed to: (1) establish the pharmacological activity in intestinal motility in vivo and antioxidant activity in vitro ; (2) perform the acute toxicology test in mouse; (3) characterize the phytochemical profile based on counter-current chromatography (CCC) and NMR analysis. The results revealed a laxative effect of S. dulcis extract and a high antioxidant activity (IC50 = 5.10 for DPPH assay and 14.14 for hydrogen peroxide scavenging test). No side effects were observed in the oral acute toxicity test for a dose up to 2000 mg/kg. The chemical profile was identified by CCC and NMR, and the comparison of the data obtained with previous literature revealed the presence of the flavonoid rutin (Quercetin-3-O-rutinoside) in the extract. |
