Enhancing cognitive control in amnestic mild cognitive impairment via at-home non-invasive neuromodulation in a randomized trial.

Autor: Jones KT; Department of Neurology, University of California-San Francisco, 675 Nelson Rising Ln, San Francisco, CA, 94158, USA. KevJones22@gmail.com.; Neuroscape, University of California-San Francisco, 675 Nelson Rising Ln, San Francisco, CA, 94158, USA. KevJones22@gmail.com.; Sandler Neurosciences Center, 675 Nelson Rising Lane, San Francisco, CA, 94158, USA. KevJones22@gmail.com., Ostrand AE; Department of Neurology, University of California-San Francisco, 675 Nelson Rising Ln, San Francisco, CA, 94158, USA.; Neuroscape, University of California-San Francisco, 675 Nelson Rising Ln, San Francisco, CA, 94158, USA., Gazzaley A; Department of Neurology, University of California-San Francisco, 675 Nelson Rising Ln, San Francisco, CA, 94158, USA.; Neuroscape, University of California-San Francisco, 675 Nelson Rising Ln, San Francisco, CA, 94158, USA.; Departments of Physiology and Psychiatry, University of California-San Francisco, 675 18th St, San Francisco, CA, 94143, USA., Zanto TP; Department of Neurology, University of California-San Francisco, 675 Nelson Rising Ln, San Francisco, CA, 94158, USA.; Neuroscape, University of California-San Francisco, 675 Nelson Rising Ln, San Francisco, CA, 94158, USA.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 May 08; Vol. 13 (1), pp. 7435. Date of Electronic Publication: 2023 May 08.
DOI: 10.1038/s41598-023-34582-1
Abstrakt: Individuals with multi-domain amnestic mild cognitive impairment (md-aMCI) have an elevated risk of dementia and need interventions that may retain or remediate cognitive function. In a feasibility pilot study, 30 older adults aged 60-80 years with md-aMCI were randomized to 8 sessions of transcranial alternating current stimulation (tACS) with simultaneous cognitive control training (CCT). The intervention took place within the participant's home without direct researcher assistance. Half of the participants received prefrontal theta tACS during CCT and the other half received control tACS. We observed high tolerability and adherence for at-home tACS + CCT. Within 1-week, only those who received theta tACS exhibited improved attentional abilities. Neuromodulation is feasible for in-home settings, which can be conducted by the patient, thereby enabling treatment in difficult to reach populations. TACS with CCT may facilitate cognitive control abilities in md-aMCI, but research in a larger population is needed to validate efficacy.
(© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
Databáze: MEDLINE
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