Association of Pregnancy and HIV Status With Molecular-Bacterial Vaginosis in Indian Women.

Autor:	Tuddenham S; Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD., Shafiq M; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY., Mathad JS; Department of Medicine, Weill Cornell Medical College, New York, NY., Alexander M; Byramjee Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Research Site, Pune, India., Naik S; Department of Obstetrics and Gynecology, Byramjee Jeejeebhoy Government Medical College, Pune, India., Kulkarni V; Byramjee Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Research Site, Pune, India., Deshpande P; Byramjee Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Research Site, Pune, India., Humphrys MS; Institute for Genome Sciences and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD., Holm JB; Institute for Genome Sciences and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD., Khan N; Byramjee Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Research Site, Pune, India., Yadana S; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY., Cheedalla A; Ohio State University School of Medicine, Columbus, OH; and., Bhosale R; Department of Obstetrics and Gynecology, Byramjee Jeejeebhoy Government Medical College, Pune, India., Ghanem KG; Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD., Wang T; Department of Biostatistics, Columbia University Mailman School of Public Health, New York, NY., Wang S; Department of Biostatistics, Columbia University Mailman School of Public Health, New York, NY., Ma B; Institute for Genome Sciences and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD., Ravel J; Institute for Genome Sciences and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD., Gupta A; Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD., Shivakoti R; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY.
Jazyk:	angličtina
Zdroj:	Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2023 Aug 15; Vol. 93 (5), pp. 422-430.
DOI:	10.1097/QAI.0000000000003215
Abstrakt:	Background: Bacterial vaginosis (BV) is a highly prevalent disorder of the cervicovaginal microbiota. Molecular-BV may put women at increased risk for adverse reproductive and obstetric outcomes. We investigated the association of HIV and pregnancy on the vaginal microbiota and associations with molecular-BV in women of reproductive age from Pune, India. Setting: We studied vaginal samples from N = 170 women, including N = 44 nonpregnant HIV seronegative, N = 56 pregnant seronegative, N = 47 nonpregnant women with HIV (WWH), and N = 23 pregnant WWH, and collected data on clinical, behavioral, and demographic factors. Methods: We used 16S rRNA gene amplicon sequencing to characterize the composition of the vaginal microbiota. We classified the vaginal microbiota of these women into community state types based on bacterial composition and relative abundance and further categorized them into molecular-BV versus Lactobacillus -dominated states. To determine associations between pregnancy and HIV status with outcome of molecular-BV, logistic regression models were used. Results: There was a high prevalence of molecular-BV (30%) in this cohort. We found that pregnancy was associated with decreased odds of molecular-BV (adjusted OR = 0.35, 95% CI: 0.14 to 0.87), while HIV was associated with increased odds of molecular-BV (adjusted OR = 2.76, 95% CI: 1.33 to 5.73), even when controlling for multiple relevant factors such as age, number of sexual partners, condom use, and douching. Conclusion: Larger and longitudinal studies are needed to further characterize molecular-BV and the vaginal microbiota in pregnant women and WWH and relate these factors to infectious, reproductive, and obstetric outcomes. In the long term, these studies may lead to novel microbiota-based therapeutics to improve women's reproductive and obstetric health. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu