Measurement of renal cortical fibrosis by CT scan.

Autor:	Olson JD; Department of Comparative Medicine, Wake Forest University, Winston-Salem, NC, 27101, USA., Tooze JA; Department of Comparative Medicine, Wake Forest University, Winston-Salem, NC, 27101, USA., Bourland DJ; Department of Comparative Medicine, Wake Forest University, Winston-Salem, NC, 27101, USA., Cline JM; Department of Comparative Medicine, Wake Forest University, Winston-Salem, NC, 27101, USA., Faria EB; Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Cohen EP; Nephrology Division, Department of Medicine, New York University Grossman School of Medicine, New York, NY, 10016, USA.
Jazyk:	angličtina
Zdroj:	Research in diagnostic and interventional imaging [Res Diagn Interv Imaging] 2023 Mar; Vol. 5. Date of Electronic Publication: 2023 Mar 01.
DOI:	10.1016/j.redii.2023.100024
Abstrakt:	Rationale and Objectives: The accurate, non-invasive, and rapid measurement of renal cortical fibrosis is needed for well-defined benchmarks of permanent injury and for use of anti-fibrotic agents. It is also needed for non-invasive and rapid assessment of the chronicity of human renal diseases. Materials and Methods: We have used a non-human primate model of radiation nephropathy to develop a novel method of size-corrected CT imaging to quantify renal cortical fibrosis. Results: Our method has an area under the receiver operating curve of 0.96, which is superior to any other non-invasive method of measuring renal fibrosis. Conclusion: Our method is suitable for immediate translation to human clinical renal diseases. Competing Interests: Declaration of Competing Interest None.
Databáze:	MEDLINE
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