Cytokines and refractory mycoplasma pneumoniae pneumonia in children: a systematic review.
| Autor: | Yu M; Medical School of Nantong University, Nantong, China.; Affiliated Hospital of Nantong University, Nantong, China., Zhang Q; Department of Nursing, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China., Yan H; Affiliated Hospital of Nantong University, Nantong, China - yho0704@163.com. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Minerva pediatrics [Minerva Pediatr (Torino)] 2024 Apr; Vol. 76 (2), pp. 259-267. Date of Electronic Publication: 2023 May 08. |
| DOI: | 10.23736/S2724-5276.23.07158-6 |
| Abstrakt: | Introduction: The relationship between cytokines and refractory mycoplasma pneumoniae pneumonia (RMPP) in children was conflicting. The aim of the current study was to perform a systematic review to determine the relationship between cytokines and RMPP in children. Evidence Acquisition: We searched PubMed, and the search was done on 21 November 2022. This search was limited to human studies, with language restriction of English. Studies were included if they reported the relationship between cytokines and RMPP. Evidence Synthesis: A total of 22 relevant full articles were included in the review. TNF-α levels in the bronchoalveolar lavage fluid (BALF) and IL-18 levels in the blood samples were likely to be associated with RMPP. IL-2 and IL-4 lost significance regardless in the BALF or blood samples. Additionally, there was no significant difference in IFN-γ levels between RMPP patients and non-refractory mycoplasma pneumoniae pneumonia (NRMPP) patients in the BALF. Patients receiving different treatments had different levels of cytokines. Conclusions: This analysis offers evidence linking abnormalities of cytokines with RMPP in children, which may be essential for identifying individuals with RMPP. Large prospective studies are needed for further clarification of roles of cytokines in RMPP. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|