Pathophysiology of multiple sclerosis damage and repair: Linking cerebral hypoperfusion to the development of irreversible tissue loss in multiple sclerosis using magnetic resonance imaging.

Autor: Mascali D; Department of Neurosciences, Imaging, and Clinical Sciences, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.; Institute for Advanced Biomedical Technologies, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy., Villani A; Department of Neurosciences, Imaging, and Clinical Sciences, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.; Institute for Advanced Biomedical Technologies, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy., Chiarelli AM; Department of Neurosciences, Imaging, and Clinical Sciences, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.; Institute for Advanced Biomedical Technologies, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy., Biondetti E; Department of Neurosciences, Imaging, and Clinical Sciences, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.; Institute for Advanced Biomedical Technologies, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy., Lipp I; Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK., Digiovanni A; Department of Neurosciences, Imaging, and Clinical Sciences, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.; MS Centre, Department of Clinical Neurology, SS. Annunziata University Hospital, Chieti, Italy., Pozzilli V; Department of Neurosciences, Imaging, and Clinical Sciences, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.; MS Centre, Department of Clinical Neurology, SS. Annunziata University Hospital, Chieti, Italy., Caporale AS; Department of Neurosciences, Imaging, and Clinical Sciences, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.; Institute for Advanced Biomedical Technologies, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy., Rispoli MG; Department of Neurosciences, Imaging, and Clinical Sciences, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.; MS Centre, Department of Clinical Neurology, SS. Annunziata University Hospital, Chieti, Italy., Ajdinaj P; Department of Neurosciences, Imaging, and Clinical Sciences, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.; MS Centre, Department of Clinical Neurology, SS. Annunziata University Hospital, Chieti, Italy., D'Apolito M; Department of Neurosciences, Imaging, and Clinical Sciences, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.; MS Centre, Department of Clinical Neurology, SS. Annunziata University Hospital, Chieti, Italy., Grasso E; Department of Neurosciences, Imaging, and Clinical Sciences, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.; Department of Paediatrics, SS. Annunziata University Hospital, Chieti, Italy., Sensi SL; Department of Neurosciences, Imaging, and Clinical Sciences, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.; Institute for Advanced Biomedical Technologies, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.; Behavioral Neurology and Molecular Neurology Units, Centre for Advanced Studies and Technology, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy., Murphy K; Cardiff University Brain Research Imaging Centre, School of Physics and Astronomy, Cardiff University, Cardiff, UK., Tomassini V; Department of Neurosciences, Imaging, and Clinical Sciences, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.; Institute for Advanced Biomedical Technologies, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK.; MS Centre, Department of Clinical Neurology, SS. Annunziata University Hospital, Chieti, Italy., Wise RG; Department of Neurosciences, Imaging, and Clinical Sciences, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.; Institute for Advanced Biomedical Technologies, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK.
Jazyk: angličtina
Zdroj: European journal of neurology [Eur J Neurol] 2023 Aug; Vol. 30 (8), pp. 2348-2356. Date of Electronic Publication: 2023 May 30.
DOI: 10.1111/ene.15827
Abstrakt: Background and Purpose: Reduced cerebral perfusion has been observed in multiple sclerosis (MS) and may contribute to tissue loss both acutely and chronically. Here, we test the hypothesis that hypoperfusion occurs in MS and relates to the presence of irreversible tissue damage.
Methods: In 91 patients with relapsing MS and 26 healthy controls (HC), gray matter (GM) cerebral blood flow (CBF) was assessed using pulsed arterial spin labeling. GM volume, T1 hypointense and T2 hyperintense lesion volumes (T1LV and T2LV, respectively), and the proportion of T2-hyperintense lesion volume that appears hypointense on T1-weighted magnetic resonance imaging (T1LV/T2LV) were quantified. GM CBF and GM volume were evaluated globally, as well as regionally, using an atlas-based approach.
Results: Global GM CBF was lower in patients (56.9 ± 12.3 mL/100 g/min) than in HC (67.7 ± 10.0 mL/100 g/min; p < 0.001), a difference that was widespread across brain regions. Although total GM volume was comparable between groups, significant reductions were observed in a subset of subcortical structures. GM CBF negatively correlated with T1LV (r = -0.43, p = 0.0002) and T1LV/T2LV (r = -0.37, p = 0.0004), but not with T2LV.
Conclusions: GM hypoperfusion occurs in MS and is associated with irreversible white matter damage, thus suggesting that cerebral hypoperfusion may actively contribute and possibly precede neurodegeneration by hampering tissue repair abilities in MS.
(© 2023 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.)
Databáze: MEDLINE
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