Altered somatic hypermutation patterns in COVID-19 patients classifies disease severity.

Autor:	Safra M; Bio-engineering, Faculty of Engineering, Bar Ilan University, Ramat Gan, Israel.; Bar Ilan Institute of Nanotechnologies and Advanced Materials, Bar Ilan University, Ramat Gan, Israel., Tamari Z; Bio-engineering, Faculty of Engineering, Bar Ilan University, Ramat Gan, Israel.; Bar Ilan Institute of Nanotechnologies and Advanced Materials, Bar Ilan University, Ramat Gan, Israel., Polak P; Bio-engineering, Faculty of Engineering, Bar Ilan University, Ramat Gan, Israel.; Bar Ilan Institute of Nanotechnologies and Advanced Materials, Bar Ilan University, Ramat Gan, Israel., Shiber S; Emergency Department, Rabin Medical Center-Belinson Campus, Petah Tikva, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Matan M; Clinical Microbiology Laboratory, Baruch Padeh Medical Center, Poriya, Israel., Karameh H; Jesselson Integrated Heart Center, Shaare Zedek Medical Center, Hebrew University School of Medicine, Jerusalem, Israel., Helviz Y; Intensive Care Unit, Shaare Zedek Medical Center, Hebrew University School of Medicine, Jerusalem, Israel., Levy-Barda A; Biobank, Department of Pathology, Rabin Medical Center-Belinson Campus, Petah Tikva, Israel., Yahalom V; Blood Services and Apheresis Institute, Rabin Medical Center, Petah Tikva, Israel., Peretz A; Clinical Microbiology Laboratory, Baruch Padeh Medical Center, Poriya, Israel.; The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel., Ben-Chetrit E; Infectious Diseases Unit, Shaare Zedek Medical Center, Hebrew University School of Medicine, Jerusalem, Israel., Brenner B; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Institute of Oncology, Rabin Medical Center-Belinson Campus, Petah Tikva, Israel., Tuller T; Department of Biomedical Engineering and The Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Gal-Tanamy M; The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel., Yaari G; Bio-engineering, Faculty of Engineering, Bar Ilan University, Ramat Gan, Israel.; Bar Ilan Institute of Nanotechnologies and Advanced Materials, Bar Ilan University, Ramat Gan, Israel.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2023 Apr 19; Vol. 14, pp. 1031914. Date of Electronic Publication: 2023 Apr 19 (Print Publication: 2023).
DOI:	10.3389/fimmu.2023.1031914
Abstrakt:	Introduction: The success of the human body in fighting SARS-CoV2 infection relies on lymphocytes and their antigen receptors. Identifying and characterizing clinically relevant receptors is of utmost importance. Methods: We report here the application of a machine learning approach, utilizing B cell receptor repertoire sequencing data from severely and mildly infected individuals with SARS-CoV2 compared with uninfected controls. Results: In contrast to previous studies, our approach successfully stratifies non-infected from infected individuals, as well as disease level of severity. The features that drive this classification are based on somatic hypermutation patterns, and point to alterations in the somatic hypermutation process in COVID-19 patients. Discussion: These features may be used to build and adapt therapeutic strategies to COVID-19, in particular to quantitatively assess potential diagnostic and therapeutic antibodies. These results constitute a proof of concept for future epidemiological challenges. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Safra, Tamari, Polak, Shiber, Matan, Karameh, Helviz, Levy-Barda, Yahalom, Peretz, Ben-Chetrit, Brenner, Tuller, Gal-Tanamy and Yaari.)
Databáze:	MEDLINE
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