CEST imaging of the APT and ssMT predict the overall survival of patients with glioma at the first follow-up after completion of radiotherapy at 3T.

Autor: von Knebel Doeberitz N; Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Kroh F; Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany., Breitling J; Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., König L; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany., Maksimovic S; Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Graß S; Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Adeberg S; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; Faculty of Medicine, University of Heidelberg, Heidelberg, Germany., Scherer M; Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany., Unterberg A; Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany; Faculty of Medicine, University of Heidelberg, Heidelberg, Germany., Bendszus M; Department of Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany; Faculty of Medicine, University of Heidelberg, Heidelberg, Germany., Wick W; Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany; Faculty of Medicine, University of Heidelberg, Heidelberg, Germany., Bachert P; Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany., Debus J; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine, University of Heidelberg, Heidelberg, Germany., Ladd ME; Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany; Faculty of Medicine, University of Heidelberg, Heidelberg, Germany., Schlemmer HP; Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine, University of Heidelberg, Heidelberg, Germany., Korzowski A; Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Goerke S; Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Paech D; Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Neuroradiology, University Hospital Bonn, Bonn, Germany. Electronic address: d.paech@dkfz.de.
Jazyk: angličtina
Zdroj: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2023 Jul; Vol. 184, pp. 109694. Date of Electronic Publication: 2023 May 06.
DOI: 10.1016/j.radonc.2023.109694
Abstrakt: Background and Purpose: Outcome prediction of patients with glioma early after the completion of radiotherapy represents a major clinical challenge. Previously, the prognostic value of chemical exchange saturation transfer (CEST) imaging has been demonstrated in patients with newly diagnosed glioma. The objective of this study was to assess the potential of amide proton transfer (APT)-, relayed nuclear Overhauser effect (rNOE)- and semi-solid magnetization transfer (ssMT)-imaging according to Zhou et al. (APTw asym ), Goerke et al. (MTR Rex APT, MTR Rex NOE and MTR Rex MT) and Mehrabian et al. (PeakAreaAPT, PeakAreaNOE and MT const ) for the prognostication of the overall survival (OS) of patients with glioma at the first follow-up after the completion of radiotherapy.
Materials and Methods: 49 of 72 participants with diffuse glioma, who underwent CEST MRI at 3T between July 2018 and December 2021 4 to 6 weeks after the completion of radiotherapy, were analyzed. Contrast-enhancing tumor (CE) and whole tumor (WT) volumes were segmented on T2w-FLAIR and contrast-enhanced T1w images. Kaplan-Meier analysis and logrank-test were used for statistical analyses.
Results: APTw imaging demonstrated the strongest association with OS (HR = 4.66, p < 0.001). The MT const (HR = 2.54, p = 0.044) was associated with the OS of participants with residual contrast-enhancing glioma tissue, whilst the MTR Rex APT (HR = 2.44, p = 0.056) showed a trend in this sub-cohort. The MTR Rex NOE, MTR Rex MT and PeakAreaNOE were not associated with survival.
Conclusion: Imaging of the APT and ssMT at the first follow-up 4 to 6 weeks after the completion of radiotherapy at 3T were associated with the overall survival of study participants with glioma.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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