Post-discharge health assessment in survivors of coronavirus disease: a time-point analysis of a prospective cohort study.

Autor: Sami R; Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Arabi S; Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran., Ghasemi K; Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran., Akafzadeh M; Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran., Ebrahimi S; Alzahra Research Institute, Alzahra University Hospital Isfahan University of Medical Sciences, Isfahan, Iran., Toghyani A; School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Mahvari R; Department of Clinical Toxicology, School of Medicine, Isfahan Clinical Toxicology Research Center, Khorshid Hospital, Isfahan University of Medical Sciences, Isfahan, Iran., Moayednia R; Arya Medical Lab Institute, Isfahan, Iran., Dadkhahi SA; Amin Hospital, Isfahan University of Medical Sciences, Isfahan, Iran., Sadeghi S; School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Marateb HR; Biomedical Engineering Research Centre (CREB), Automatic Control Department (ESAII), Universitat Politècnica de Catalunya-Barcelona, 08028, Barcelona, Spain., Adibi P; Isfahan Gastroenterology and Hepatology Research Center, Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Kavosh A; School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Mansourian M; Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran. marjan.mansourian@upc.edu.; Biomedical Engineering Research Centre (CREB), Automatic Control Department (ESAII), Universitat Politècnica de Catalunya-Barcelona, 08028, Barcelona, Spain. marjan.mansourian@upc.edu.
Jazyk: angličtina
Zdroj: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation [Qual Life Res] 2023 Sep; Vol. 32 (9), pp. 2681-2693. Date of Electronic Publication: 2023 May 07.
DOI: 10.1007/s11136-023-03415-z
Abstrakt: Purpose:  The objective of this study was to quantitatively evaluate psychological and quality of life-related complications at three months following discharge in hospitalized coronavirus disease 2019 (COVID-19) patients during the pandemic in Iran.
Methods: In this time-point analysis of prospective cohort study data, adult patients hospitalized with symptoms suggestive of COVID-19 were enrolled. Patients were stratified in analyses based on severity. The primary outcomes consisted of psychological problems and pulmonary function tests (PFTs) in the three months following discharge, with Health-related quality of life (HRQoL) as the secondary outcome. Exploratory predictors were determined for both primary and secondary outcomes.
Results: 283 out of 900 (30%) eligible patients were accessible for the follow-up assessment and included in the study. The mean age was 53.65 ± 13.43 years, with 68% experiencing a severe disease course. At the time of the final follow-up, participants still reported persistent symptoms, among which fatigue, shortness of breath, and cough were the most common. Based on the regression-adjusted analysis, lower levels of forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) ratio was associated with higher levels of depression (standardized β = - 0.161 (SE = 0.042), P = 0.017) and stress levels (standardized β =- 0.110 (SE = 0.047), P = 0.015). Furthermore, higher levels of anti-SARS-CoV-2 immunoglobulin-M (IgM) were associated with significantly lower levels of depression (standardized β = - 0.139 (SE = 0.135), P = 0.031).
Conclusions: There is an association between lung damage during COVID-19 and the reduction of pulmonary function for up to three months from acute infection in hospitalized patients. Varying degrees of anxiety, depression, stress, and low HRQoL frequently occur in patients with COVID-19. More severe lung damage and lower COVID-19 antibodies were associated with lower levels of psychological health.
(© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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