Advanced cancer targeting using aptamer functionalized nanocarriers for site-specific cargo delivery.

Autor: Narwade M; Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth, Pune, India., Shaikh A; Nanobioscience Group, Agharkar Research Institute, Pune, 411004, India.; Savitribai Phule Pune University, Ganeshkhind, Pune, 411 007, India., Gajbhiye KR; Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth, Pune, India., Kesharwani P; Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India. prashantdops@gmail.com.; Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Chennai, India. prashantdops@gmail.com., Gajbhiye V; Nanobioscience Group, Agharkar Research Institute, Pune, 411004, India. cme_virendra@yahoo.co.in.; Savitribai Phule Pune University, Ganeshkhind, Pune, 411 007, India. cme_virendra@yahoo.co.in.
Jazyk: angličtina
Zdroj: Biomaterials research [Biomater Res] 2023 May 06; Vol. 27 (1), pp. 42. Date of Electronic Publication: 2023 May 06.
DOI: 10.1186/s40824-023-00365-y
Abstrakt: The non-specificity of standard anticancer therapies has profound detrimental consequences in clinical treatment. Therapeutic specificity can be precisely achieved using cutting-edge ligands. Small synthetic oligonucleotide-ligands chosen through Systematic evolution of ligands by exponential enrichment (SELEX) would be an unceasing innovation in using nucleic acids as aptamers, frequently referred to as "chemical antibodies." Aptamers act as externally controlled switching materials that can attach to various substrates, for example, membrane proteins or nucleic acid structures. Aptamers pose excellent specificity and affinity for target molecules and can be used as medicines to suppress tumor cell growth directly. The creation of aptamer-conjugated nanoconstructs has recently opened up innovative options in cancer therapy that are more effective and target tumor cells with minor toxicity to healthy tissues. This review focuses on a comprehensive description of the most capable classes of aptamer-tethered nanocarriers for precise recognition of cancer cells with significant development in proficiency, selectivity, and targetability for cancer therapy. Existing theranostic applications with the problems and future directions are also highlighted.
(© 2023. The Author(s).)
Databáze: MEDLINE
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