Reduced syntactic recursion in spontaneous speech of Parkinson's disease patients.

Autor: Henkel J; Department of Neurology and Center of Brain, Behaviour and Metabolism, University of Lübeck, Germany; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany. Electronic address: julia.henkel@neuro.uni-luebeck.de., Hartmann C; Department of Neurology, Medical Faculty, University Medical Center Düsseldorf, Germany; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany., Niccolai V; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany., van de Vijver R; Institute of Language and Information, Philosophical Faculty, Heinrich-Heine-University Düsseldorf, Germany., Schnitzler A; Department of Neurology, Medical Faculty, University Medical Center Düsseldorf, Germany; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany., Biermann-Ruben K; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany.
Jazyk: angličtina
Zdroj: Acta psychologica [Acta Psychol (Amst)] 2023 Jun; Vol. 236, pp. 103931. Date of Electronic Publication: 2023 May 04.
DOI: 10.1016/j.actpsy.2023.103931
Abstrakt: Although characterized as a movement disorder, Parkinson's disease (PD) affects more than just the motor system. Within the heterogenous non-motor symptoms, language impairment is frequent but poorly understood beyond semantic processing. This study investigates the impact of PD on syntactic subordination in spontaneous language production. Fifteen PD patients in ON levodopa status narrated a short story guided by a set of pictures. Thirteen PD patients were also assessed in OFF levodopa status. Narrations were digitally recorded, subsequently transcribed and annotated, making the produced speech accessible to systematical quantitative analysis. Compared to a healthy matched control group, PD patients showed a significant reduction of subordinating structures while the number of non-embedding sentences remained unaffected. No significant effect comparing ON versus OFF levodopa status emerged. Our results suggest a contribution of the basal ganglia to language processing, such as syntactic composition, which, however, does not seem to be dopamine dependent.
Competing Interests: Declaration of competing interest This study was conducted with financial support of the DFGCRC991. Parts of this work were published as part of the dissertation project of Julia Henkel: “Sprachstörungen als nicht-motorisches Symptom bei Morbus Parkinson/Speech impairment as a non-motor symptom in Parkinson's Disease” (https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=54872). All authors declare that they have no conflicts of interest.
(Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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