The inverse electron demand Diels-Alder cycloaddition with carbon-11 and fluorine-18: A gateway to pretargeted imaging across the blood-brain barrier.

Autor: Zientek SH; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Thompson S; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Sephton SM; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Aigbirhio FI; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Jazyk: angličtina
Zdroj: Journal of labelled compounds & radiopharmaceuticals [J Labelled Comp Radiopharm] 2023 Jul; Vol. 66 (9), pp. 249-268. Date of Electronic Publication: 2023 May 18.
DOI: 10.1002/jlcr.4029
Abstrakt: There is increased focus on developing tools to image large biomolecules, such as antibodies, within the brain using positron emission tomography (PET). The inverse electron demand Diels-Alder cycloaddition (IEDDA) reaction has offered the greatest prospect of achieving such a feat and has gained much interest over the past decade. The fast reaction kinetics of the IEDDA reaction opens up the possibility of utilising a pretargeted approach, whereby the subject is pretreated with a biomolecule that has high specificity for its target. A radiolabelled second component is then administered to the subject, enabling the biomolecule to be visualised by PET. However, for this to become common practice, there is a need for the development of either radiolabelled trans-cyclooctenes (TCOs) or tetrazines that can cross the blood-brain barrier (BBB). This review highlights the advancements in the development of both radiolabelled TCOs and tetrazines, which have been radiolabelled with either carbon-11 or fluorine-18 and show promise or have been evaluated for use in pretargeted PET imaging across the BBB.
(© 2023 The Authors. Journal of Labelled Compounds and Radiopharmaceuticals published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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