Risk of adverse pregnancy and infant outcomes associated with prenatal Zika virus infection: a post-epidemic cohort in Central-West Brazil.

Autor: Rosado LEP; Graduate Program in Tropical Medicine and Public Health of the Federal University of Goias, Goiânia, Brazil.; Obstetrics Department, Maternal and Infant Hospital of Goias State, Goiânia, Brazil., Martelli CMT; Institute Aggeu Magalhaes, Fiocruz/Pernambuco, Recife, Brazil., Brickley EB; Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom., Gomes MBF; Graduate Program in Health Sciences of the Federal University of Goias, Goiânia, Brazil.; Pediatric Department, Maternal and Infant Hospital of Goias State, Goiânia, Brazil., de Toledo Lima T; Graduate Program in Health Sciences of the Federal University of Goias, Goiânia, Brazil.; Reference Center in Ophthalmology of the Federal University of Goias, Goiânia, Brazil., da Costa PSS; Pediatrics Department, School of Medicine, Federal University of Goiás, Goiânia, Brazil., de Ávila MP; Reference Center in Ophthalmology of the Federal University of Goias, Goiânia, Brazil.; Retina and Vitreous Department, School of Medicine, Federal University of Goias, Goiânia, Brazil., Viggiano MB; Ultrasound Department, Maternal and Infant Hospital of Goias State, Goiânia, Brazil., do Amaral WN; Obstetrics Department, School of Medicine, Federal University of Goias, Goiânia, Brazil., de Rezende Feres VC; Faculty of Pharmacy, Federal University of Goias, Goiânia, Brazil., Fiaccadori FS; Virology Department, Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiânia, Brazil., de Sene Amancio Zara AL; Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiânia, Brazil., Ferreira-Lopes A; Faculty of Pharmacy, Federal University of Goias, Goiânia, Brazil., Turchi MD; Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiânia, Brazil. marilia.turchi@gmail.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 May 05; Vol. 13 (1), pp. 7335. Date of Electronic Publication: 2023 May 05.
DOI: 10.1038/s41598-023-33334-5
Abstrakt: This study aimed to estimate the risks of adverse infant outcomes in the first year of life related to prenatal Zika virus (ZIKV) exposure. A prospective cohort of pregnant women with rash was recruited in Central-West Brazil in a post-epidemic period (January 2017 to April 2019). We evaluated participants' medical histories and performed ZIKV diagnostic testing using molecular (reverse transcription polymerase chain reaction [RT-PCR]) and serologic (immunoglobulin [Ig]M and plaque reduction neutralization tests [PRNT 90 ]) assays. The ZIKV-positive group included both RT-PCR-confirmed cases as well as IgM and/or PRNT 90 -positive probable cases. Children were evaluated at birth and in the first 12 months of life. Transfontanellar ultrasound, central nervous system computed tomography, eye fundoscopy and retinography were performed. We estimated the absolute risk and 95% confidence interval (95% CI) of adverse infant outcomes among confirmed prenatally ZIKV-exposed children. Among 81 pregnant women with rash, 43 (53.1%) were ZIKV infected. The absolute risk of microcephaly among offspring of ZIKV-infected pregnant women was 7.0% (95% CI: 1.5-19.1), including the two cases of microcephaly detected prenatally and one detected postnatally. In total, 54.5% (95% CI: 39.8-68.7) of children in the ZIKV-exposed group had at least one ophthalmic abnormality, with the most frequent abnormalities being focal pigmentary mottling and chorioretinal atrophy or scarring. Our findings reinforce the importance of long-term monitoring of prenatally ZIKV-exposed children born apparently asymptomatic for Congenital Zika Syndrome.
(© 2023. The Author(s).)
Databáze: MEDLINE
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