Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes.
| Autor: | Hogrebe NJ; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, MSC 8127-057-08, 660 South Euclid Avenue, St. Louis, MO 63130, USA. Electronic address: nhogrebe@wustl.edu., Ishahak M; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, MSC 8127-057-08, 660 South Euclid Avenue, St. Louis, MO 63130, USA., Millman JR; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, MSC 8127-057-08, 660 South Euclid Avenue, St. Louis, MO 63130, USA; Department of Biomedical Engineering, Washington University in St. Louis, 1 Brookings Drive, St. Louis, MO 63130, USA. Electronic address: jmillman@wustl.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Cell stem cell [Cell Stem Cell] 2023 May 04; Vol. 30 (5), pp. 530-548. |
| DOI: | 10.1016/j.stem.2023.04.002 |
| Abstrakt: | The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs) has the potential to provide an unlimited source of insulin-producing β cells for the treatment of diabetes. In order for this cell therapy to become widely adopted, highly functional and well-characterized stem cell-derived islets (SC-islets) need to be manufactured at scale. Furthermore, successful SC-islet replacement strategies should prevent significant cell loss immediately following transplantation and avoid long-term immune rejection. This review highlights the most recent advances in the generation and characterization of highly functional SC-islets as well as strategies to ensure graft viability and safety after transplantation. Competing Interests: Declaration of interests N.J.H. and J.R.M. are inventors on patents and patent applications related to SC-islets. J.R.M. is an employee and has stock or stock options in Sana Biotechnology. M.I. has stock in Vertex Pharmaceuticals. (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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