Calcaneal broadband ultrasound attenuation predicts physical capability: EPIC-Norfolk prospective population-based study.

Autor: Perrott SL; Ageing Clinical & Experimental Research (ACER) Team, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK. Electronic address: sarahperrott@doctors.org.uk., Martin K; Academic Primary Care, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK; The Aberdeen Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK., Keevil VL; Department of Medicine, University of Cambridge, UK., Wareham NJ; MRC Epidemiology Unit, Cambridge, UK., Khaw KT; Department of Medicine, University of Cambridge, UK., Myint PK; Ageing Clinical & Experimental Research (ACER) Team, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
Jazyk: angličtina
Zdroj: Maturitas [Maturitas] 2023 Jul; Vol. 173, pp. 7-15. Date of Electronic Publication: 2023 Apr 20.
DOI: 10.1016/j.maturitas.2023.04.008
Abstrakt: Background: Calcaneal ultrasound (broadband ultrasound attenuation - BUA), a marker of bone strength, may predict future physical capability and thus provide a strategy to identify individuals at risk of age-related deterioration of health. This study aims to determine if BUA can predict future physical capability among middle-aged and older adults.
Methods: Summary performance scores (SPS), an objective quantification of physical capability, were devised using participants' measures of standing balance, gait speed and timed chair rises. Associations between BUA and SPS, measured at least six years apart, were investigated using univariable and multivariate sex-specific linear and logistic regression, adjusting for confounders.
Results: 5893 participants were included. In men and women, for every five points lower BUA, there was a 0.2-point decrease in SPS. In women, BUA less than one standard deviation below the mean was associated with low physical capability (defined as SPS 3-6); fully adjusted odds ratio (OR) (95 % confidence interval (CI)) 1.35 (1.01-1.84). No association existed among men; OR (95 % CI) 0.84 (0.59-1.19). Significant risk factors for low physical capability in men with baseline low BUA were: older age [OR 5.77]; high BMI [OR 2.85]; lower social class [OR 1.59]; low physical activity [OR 1.64]. Risk factors among women were: older age [OR 5.54]; high BMI [OR 2.08]; lower education [OR 1.42], low physical activity [OR 1.27]; steroid use [OR 2.05]; and stroke [OR 2.74].
Conclusion: BUA may predict future physical capability in older adults. With further validation, BUA could stratify individuals at risk of deterioration in physical health.
Competing Interests: Declaration of competing interest Sarah Perrott, Kathryn Martin, Victoria L Keevil, Nicholas J Wareham, Kay-Tee Khaw, and Phyo Kyaw Myint declare that they have no competing interests.
(Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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