Modeling SARS-CoV-2 antibody seroprevalence and its determinants in Ghana: A nationally representative cross-sectional survey.

Autor:	Owusu Donkor I; Epidemiology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Mensah SK; Epidemiology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Dwomoh D; Department of Biostatistics, School of Public Health, University of Ghana, Legon, Ghana., Akorli J; Parasitology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Abuaku B; Epidemiology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Ashong Y; Parasitology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Opoku M; Parasitology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Andoh NE; Parasitology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Sumboh JG; Parasitology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Ohene SA; Emergency Preparedness and Response Unit, World Health Organization, Country Office, Accra, Ghana., Owusu-Asare AA; Emergency Preparedness and Response Unit, World Health Organization, Country Office, Accra, Ghana., Quartey J; Parasitology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Dumashie E; Parasitology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Lomotey ES; Parasitology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Odumang DA; Parasitology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Gyamfi GO; Epidemiology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Dorcoo C; Epidemiology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Afatodzie MS; Parasitology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Osabutey D; Epidemiology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Ismail RBY; Parasitology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Quaye I; Parasitology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Bosomprah S; Department of Biostatistics, School of Public Health, University of Ghana, Legon, Ghana., Munster V; Virus Ecology Section, Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America., Koram KA; Epidemiology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Jazyk:	angličtina
Zdroj:	PLOS global public health [PLOS Glob Public Health] 2023 May 05; Vol. 3 (5), pp. e0001851. Date of Electronic Publication: 2023 May 05 (Print Publication: 2023).
DOI:	10.1371/journal.pgph.0001851
Abstrakt:	Estimates of SARS-CoV-2 transmission rates have significant public health policy implications since they shed light on the severity of illness in various groups and aid in strategic deployment of diagnostics, treatment and vaccination. Population-based investigations have not been conducted in Ghana to identify the seroprevalence of SARS-CoV-2. We conducted an age stratified nationally representative household study to determine the seroprevalence of SARS-CoV-2 and identify risk factors between February and December 2021. Study participants, 5 years and older regardless of prior or current infection COVID-19 infection from across Ghana were included in the study. Data on sociodemographic characteristics, contact with an individual with COVID-19-related symptoms, history of COVID-19-related illness, and adherence to infection prevention measures were collected. Serum obtained was tested for total antibodies with the WANTAI ELISA kit. The presence of antibodies against SAR-COV-2 was detected in 3,476 of 5,348 participants, indicating a seroprevalence of 67.10% (95% CI: 63.71-66.26). Males had lower seroprevalence (65.8% [95% CI: 63.5-68.04]) than females (68.4% [95% CI: 66.10-69.92]). Seroprevalence was lowest in >20 years (64.8% [95% CI: 62.36-67.19]) and highest among young adults; 20-39 years (71.1% [95% CI 68.83,73.39]). Seropositivity was associated with education, employment status and geographic location. Vaccination status in the study population was 10%. Exposure is more likely in urban than rural areas thus infection prevention protocols must be encouraged and maintained. Also, promoting vaccination in target groups and in rural areas is necessary to curb transmission of the virus. Competing Interests: The authors have declared that no competing interests exist. (Copyright: © 2023 Owusu Donkor et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze:	MEDLINE
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