Sufficient vitamin D is favorable for children with persistent and chronic immune thrombocytopenia.

Autor: Mabrouk RE; Pediatric Department, Al-Thawra Teaching Hospital, Omar Al-Mukhtar University, Al Bayda, Libya., Hussein DT; Medical Analysis & Biochemistry, Faculty of Medicine, Mansoura University Children Hospital, Mansoura University, Mansoura, Egypt., Abbas MEER; Pediatric Department, Faculty of Medicine, Mansoura University Children Hospital, Mansoura University, Mansoura, Egypt., Mabood SAE; Pediatric Hematology, Oncology and Bone Marrow Transplantation Unit, Faculty of Medicine, Mansoura University Children Hospital, Mansoura University, Mansoura, 35516, Egypt. suzyabdelmabood@yahoo.com.
Jazyk: angličtina
Zdroj: Annals of hematology [Ann Hematol] 2023 Aug; Vol. 102 (8), pp. 2033-2038. Date of Electronic Publication: 2023 May 05.
DOI: 10.1007/s00277-023-05210-9
Abstrakt: Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia in the absence of other disorders. Vitamin D (VD) has been shown to modulate the immune system and its deficiency is linked to many immunological disorders. Supplementation with VD in ITP has promising results. This work aims at evaluating VD values in children with persistent and chronic ITP and the effect of its deficiency on disease severity and treatment response. A case-control study including 50 persistent and chronic ITP patients and 50 healthy controls was conducted. 25 OH vitamin D level was determined using ELISA technique. VD median value was significantly higher among the control group than that of the patients' group (28 vs 21.5 and p = 0.002). Severe deficiency was detected significantly more among the patients' group than the control group (12 (24%) vs 3 (6%), p = 0.048) respectively. Forty-four percent of complete responders belong to sufficient VD category ((15/34) ~ 44% (p = 0.005)) representing all patients with sufficient VD status (n = 15). Also, a positive correlation between serum level of vitamin D and mean PLT count was observed (r = 0.316, p value = 0.025). Sufficient vitamin D was associated with better treatment response and less disease severity. Vitamin D supplementation may be a new therapeutic option for chronic ITP.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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