Serum levels of leptin and adiponectin in patients with autoimmune Hashimoto's thyroiditis.

Autor: Tomov DG; Medical University of Plovdiv, Plovdiv, Bulgaria., Levterova BA; Medical University of Plovdiv, Plovdiv, Bulgaria., Troev DM; Medical University of Plovdiv, Plovdiv, Bulgaria., Miteva MZ; Medical University of Plovdiv, Plovdiv, Bulgaria., Mihaylova VN; Medical University of Plovdiv, Plovdiv, Bulgaria., Uzunova YI; Medical University of Plovdiv, Plovdiv, Bulgaria., Divarova VV; Medical University of Plovdiv, Plovdiv, Bulgaria., Orbetzova MM; Medical University of Plovdiv, Plovdiv, Bulgaria.
Jazyk: angličtina
Zdroj: Folia medica [Folia Med (Plovdiv)] 2023 Apr 30; Vol. 65 (2), pp. 199-206.
DOI: 10.3897/folmed.65.e75390
Abstrakt: Introduction: Adipose tissue is immunologically and hormonally active, and these effects are mediated largely by adipocytokines. Thyroid hormones regulate metabolism and organ function, and Hashimoto's thyroiditis (HT) is the most common autoimmune disease affecting thyroid function.
Aim: To evaluate the levels of the adipocytokines leptin and adiponectin in patients with autoimmune HT, and to perform a comparative intragroup analysis in patients with different stages of gland functional activity, and in a control group.
Materials and Methods: Ninety-five patients with HT and 21 healthy controls were enrolled in the study. Venous blood was taken without anticoagulants after at least 12 hours of fasting, and serum samples were frozen at -70°C until analysis. Serum levels of leptin and adiponectin were determined by an enzyme-linked immunosorbent assay (ELISA).
Results: Serum levels of leptin in HT patients were higher than those in the control group (4.5±5.2 ng/mL vs. 1.9±1.3 ng/mL). The hypothyroid patient's group showed significantly higher levels of leptin than those of the healthy controls (5.1±5.2 ng/mL vs. 1.9±1.3 ng/mL), (p=0.031). Leptin levels correlated positively with body mass index (r=0.533, p.
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Databáze: MEDLINE
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