The Impact of Diabetes Mellitus on Clinical Outcomes after Percutaneous Coronary Intervention with Different Stent Sizes.

Autor:	Zibaeenezhad MJ; Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Sayadi M; Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Mohammadi SS; Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Khorshidi S; Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Hadiyan E; Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Rasouli N; University of Colorado, School of Medicine, and VA Eastern Colorado Health Care System, Aurora, Colorado, USA., Karimi-Akhormeh A; Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Razeghian-Jahromi I; Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Jazyk:	angličtina
Zdroj:	The journal of Tehran Heart Center [J Tehran Heart Cent] 2022 Oct; Vol. 17 (4), pp. 207-214.
DOI:	10.18502/jthc.v17i4.11609
Abstrakt:	Background: This study aimed to investigate the possible relationship between different stent sizes and clinical outcomes after percutaneous coronary intervention (PCI) in patients with diabetes treated with drug-eluting stents (DESs) and dual antiplatelet therapy (DAPT). Methods: Patients with stable coronary artery disease undergoing elective PCI with the DES were entered into a retrospective cohort between 2003 and 2019. Major adverse cardiac events (MACE), defined as the combined endpoint of revascularization, myocardial infarction, and cardiovascular death, were recorded. The participants were categorized according to the stent size: 27 mm for length and 3 mm for diameter. DAPT (aspirin and clopidogrel) was used for at least 2 years for diabetics and 1 year for nondiabetics. The median duration of follow-up was 74.7 months. Results: Out of 1630 participants, 29.0% had diabetes. The diabetics constituted 37.8% of those with MACE. The mean diameter of the stents in the diabetics and nondiabetics was 2.81±0.29 mm and 2.90±0.35 mm, respectively (P>0.05). The mean stent length was 19.48±7.58 mm and 18.92±6.64 mm in the diabetics and nondiabetics, respectively (P>0.05). After adjustments for confounding variables, MACE was not significantly different between the patients with and without diabetes. Although MACE incidence was not affected by stent dimensions in the patients with diabetes, the nondiabetic patients implanted with a stent length exceeding 27 mm experienced MACE less frequently. Conclusion: Diabetes did not influence MACE in our population. Additionally, stents of different sizes were not associated with MACE in patients with diabetes. We propose that using the DES supplemented by long-term DAPT and tight control of glycemic status after PCI could decrease the adverse consequences of diabetes. (Copyright © 2022 Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences.)
Databáze:	MEDLINE
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