Cortico-muscular coherence in primary lateral sclerosis reveals abnormal cortical engagement during motor function beyond primary motor areas.

Autor:	Bista S; Academic Unit of Neurology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin 2, Ireland., Coffey A; Academic Unit of Neurology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin 2, Ireland., Fasano A; Academic Unit of Neurology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin 2, Ireland., Buxo T; Academic Unit of Neurology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin 2, Ireland., Mitchell M; Academic Unit of Neurology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin 2, Ireland., Giglia ER; Academic Unit of Neurology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin 2, Ireland., Dukic S; Academic Unit of Neurology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin 2, Ireland.; Department of Neurology, University Medical Centre Utrecht Brain Centre, Utrecht University, Utrecht 3584 CG, The Netherlands., Heverin M; Academic Unit of Neurology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin 2, Ireland., Muthuraman M; Neural Engineering with Signal Analytics and Artificial Intelligence, Department of Neurology, University Hospital Würzburg, Würzburg 97080, Germany., Carson RG; Trinity College Institute of Neuroscience and School of Psychology, Trinity College Dublin,, Dublin 2, Ireland.; School of Psychology, Queen's University Belfast, Belfast BT71NN, UK., Lowery M; School of Electrical and Electronic Engineering, University College Dublin, Dublin 4, Ireland., Hardiman O; Academic Unit of Neurology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin 2, Ireland.; Beaumont Hospital, Dublin 9, Ireland., McManus L; Academic Unit of Neurology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin 2, Ireland., Nasseroleslami B; Academic Unit of Neurology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin 2, Ireland.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2023 Jun 20; Vol. 33 (13), pp. 8712-8723.
DOI:	10.1093/cercor/bhad152
Abstrakt:	Primary lateral sclerosis (PLS) is a slowly progressing disorder, which is characterized primarily by the degeneration of upper motor neurons (UMNs) in the primary motor area (M1). It is not yet clear how the function of sensorimotor networks beyond M1 are affected by PLS. The aim of this study was to use cortico-muscular coherence (CMC) to characterize the oscillatory drives between cortical regions and muscles during a motor task in PLS and to examine the relationship between CMC and the level of clinical impairment. We recorded EEG and EMG from hand muscles in 16 participants with PLS and 18 controls during a pincer-grip task. In PLS, higher CMC was observed over contralateral-M1 (α- and γ-band) and ipsilateral-M1 (β-band) compared with controls. Significant correlations between clinically assessed UMN scores and CMC measures showed that higher clinical impairment was associated with lower CMC over contralateral-M1/frontal areas, higher CMC over parietal area, and both higher and lower CMC (in different bands) over ipsilateral-M1. The results suggest an atypical engagement of both contralateral and ipsilateral M1 during motor activity in PLS, indicating the presence of pathogenic and/or adaptive/compensatory alterations in neural activity. The findings demonstrate the potential of CMC for identifying dysfunction within the sensorimotor networks in PLS. (© The Author(s) 2023. Published by Oxford University Press.)
Databáze:	MEDLINE
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