The impact of epigenetic landscape on ovarian cells in infertile older women undergoing IVF procedures.

Autor: Sgueglia G; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Programma di Epigenetica Medica, Azienda Ospedaliera Universitaria, Naples, Italy., Longobardi S; Merck KGaA, 64293, Darmstadt, Germany., Valerio D; Outpatient Fertility Unit, University of Campania 'Luigi Vanvitelli', 80138, Naples, Italy., Campitiello MR; Department of Obstetrics and Gynecology and Physiopathology of Human Reproduction, ASL Salerno, Salerno, Italy., Colacurci N; Outpatient Fertility Unit, University of Campania 'Luigi Vanvitelli', 80138, Naples, Italy.; Department of Woman, Child and General and Special Surgery, University of Campania 'Luigi Vanvitelli', 80138, Naples, Italy., Di Pietro C; Department of Biomedical and Biotechnological Sciences, Section of Biology and Genetics 'Giovanni Sichel', University of Catania, 95123, Catania, CT, Italy., Battaglia R; Department of Biomedical and Biotechnological Sciences, Section of Biology and Genetics 'Giovanni Sichel', University of Catania, 95123, Catania, CT, Italy., D'Hooghe T; Merck KGaA, 64293, Darmstadt, Germany., Altucci L; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Programma di Epigenetica Medica, Azienda Ospedaliera Universitaria, Naples, Italy. lucia.altucci@unicampania.it.; BIOGEM, Ariano Irpino, Italy. lucia.altucci@unicampania.it.; Institute of Experimental Endocrinology and Oncology 'Gaetano Salvatore' (IEOS)-National Research Council (CNR), Naples, Italy. lucia.altucci@unicampania.it., Dell'Aversana C; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Programma di Epigenetica Medica, Azienda Ospedaliera Universitaria, Naples, Italy. carmela.dellaversana@cnr.it.; Institute of Experimental Endocrinology and Oncology 'Gaetano Salvatore' (IEOS)-National Research Council (CNR), Naples, Italy. carmela.dellaversana@cnr.it.
Jazyk: angličtina
Zdroj: Clinical epigenetics [Clin Epigenetics] 2023 May 04; Vol. 15 (1), pp. 76. Date of Electronic Publication: 2023 May 04.
DOI: 10.1186/s13148-023-01490-0
Abstrakt: The constant decline in fertility and older reproductive age is the major cause of low clinical pregnancy rates in industrialised countries. Epigenetic mechanisms impact on proper embryonic development in women undergoing in vitro fertilisation (IVF) protocols. Here, we describe the main epigenetic modifications that may influence female reproduction and could affect IVF success.
(© 2023. The Author(s).)
Databáze: MEDLINE
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