Coexistence of malignancies in pemphigus vulgaris.

Autor: Warshavsky K; Department of Dermatology, Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.; Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Zeeli T; Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Mekiten O; Department of Dermatology, Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.; Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Sprecher E; Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Department of Human Molecular Genetics & Biochemistry, Tel Aviv University, Tel-Aviv, Israel., Silverman BG; Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Israel National Cancer Registry, Israel Center for Disease Control, Israel Ministry of Health, Jerusalem, Israel., Barzilai A; Department of Dermatology, Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.; Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Institute of Pathology, Sheba Medical Center, Ramat-Gan, Israel., Baum S; Department of Dermatology, Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel. baumdr@gmail.com.; Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. baumdr@gmail.com.
Jazyk: angličtina
Zdroj: Immunologic research [Immunol Res] 2023 Oct; Vol. 71 (5), pp. 743-748. Date of Electronic Publication: 2023 May 04.
DOI: 10.1007/s12026-023-09388-y
Abstrakt: Pemphigus vulgaris (PV) is a rare autoimmune intraepidermal bullous disease. PV has a major effect on morbidity as well as quality of life. There is sparse literature regarding the association between pemphigus vulgaris (PV) and comorbid malignancies. In this study we aimed to assess the risk of malignancy in a cohort of patients with PV and characterize PV-associated malignancies. Data were collected from two tertiary referral centers between the years 2008 and 2019 and compared with the national cancer registry. Of 164 patients with PV, 19 were diagnosed with malignancy: seven prior to PV diagnosis and 12 after. All cancers, solid and hematological, displayed higher incidences compared to the general population (p <0.001). In conclusion, we demonstrated higher rates of malignancies among patients with PV than in the general population. These observations suggest the need for careful assessment and follow up of patients with PV, given the possibility of associated malignancies.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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