Adenomatoid odontogenic tumor: Features of ameloblastic-like epithelial cells differentiation, secretion, and the nature of tumor cells products.

Autor: Passador-Santos F; Department of Oral Pathology, Faculdade São Leopoldo Mandic, São Paulo, Brazil., de Oliveira CRR; Department of Oral Pathology, Faculdade São Leopoldo Mandic, São Paulo, Brazil.; Centro Universitário CESMAC, Faculdade de Odontologia, Maceió, Brazil., Teixeira LN; Department of Oral Pathology, Faculdade São Leopoldo Mandic, São Paulo, Brazil., Turssi CP; Department of Oral Pathology, Faculdade São Leopoldo Mandic, São Paulo, Brazil., de Brito-Junior RB; Department of Oral Pathology, Faculdade São Leopoldo Mandic, São Paulo, Brazil., Soares AB; Department of Oral Pathology, Faculdade São Leopoldo Mandic, São Paulo, Brazil., de Freitas NS; Department of Oral Pathology, Faculdade São Leopoldo Mandic, São Paulo, Brazil., de Araújo NS; Department of Oral Pathology, Faculdade São Leopoldo Mandic, São Paulo, Brazil., de Araújo VC; Department of Oral Pathology, Faculdade São Leopoldo Mandic, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2023 Aug; Vol. 52 (7), pp. 644-653. Date of Electronic Publication: 2023 May 04.
DOI: 10.1111/jop.13436
Abstrakt: Background: This study aimed to investigate the differentiation of ameloblastic-like cells and the nature of the secreted eosinophilic materials in adenomatoid odontogenic tumors.
Methods: We studied histological and immunohistochemical characteristics of 20 cases using: cytokeratins 14 and 19, amelogenin, collagen I, laminin, vimentin, and CD34.
Results: Rosette cells differentiated into ameloblastic-like cells positioned face-to-face, displaying collagen I-positive material between them. Epithelial cells of the rosettes can differentiate into ameloblastic-like cells. This phenomenon probably occurs due to an induction phenomenon between these cells. The secretion of collagen I is probably a brief event. Amelogenin-positive areas were interspersed by epithelial cells in the lace-like areas, outside the rosettes and distant from the ameloblastic-like cells.
Conclusions: There are at least two types of eosinophilic material in different areas within the tumor, one in the rosette and solid areas and another in lace-like areas. The secreted eosinophilic material in the rosettes and solid areas is probably a product of well-differentiated ameloblastic-like cells. It is positive for collagen I and negative for amelogenin, whereas some eosinophilic materials in the lace-like areas are positive for amelogenin. We hypothesize that the latter eosinophilic material could be a product of odontogenic cuboidal epithelial or intermediate stratum-like epithelial cells.
(© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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