Application of 1,000 fps High-Speed Angiography to In-Vitro Hemodynamic Evaluation of Left Ventricular Assist Device Outflow Graft Configurations.

Autor:	Shields A; From the Department of Radiology, Medical Physics Program, University at Buffalo School of Medicine, Buffalo, New York.; Biomedical Sciences, Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo, New York., Setlur Nagesh SV; From the Department of Radiology, Medical Physics Program, University at Buffalo School of Medicine, Buffalo, New York.; Biomedical Sciences, Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo, New York., Rajagopal K; Division of Cardiac Surgery, Department of Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania., Bednarek DR; From the Department of Radiology, Medical Physics Program, University at Buffalo School of Medicine, Buffalo, New York.; Biomedical Sciences, Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo, New York., Rudin S; From the Department of Radiology, Medical Physics Program, University at Buffalo School of Medicine, Buffalo, New York.; Biomedical Sciences, Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo, New York., Chivukula VK; Department of Biomedical Engineering, Florida Institute of Technology, Melbourne, Florida.
Jazyk:	angličtina
Zdroj:	ASAIO journal (American Society for Artificial Internal Organs : 1992) [ASAIO J] 2023 Aug 01; Vol. 69 (8), pp. 756-765. Date of Electronic Publication: 2023 May 03.
DOI:	10.1097/MAT.0000000000001948
Abstrakt:	Left ventricular assist device (LVAD)-induced hemodynamics are characterized by fast-moving flow with large variations in velocity, making quantitative assessments difficult with existing imaging methods. This study demonstrates the ability of 1,000 fps high-speed angiography (HSA) to quantify the effect of the surgical implantation angle of a LVAD outflow graft on the hemodynamics within the ascending aorta in vitro . High-speed angiography was performed on patient-derived, three-dimensional-printed optically opaque aortic models using a nonsoluble contrast media, ethiodol, as a flow tracer. Outflow graft configuration angles of 45° and 90° with respect to the central aortic axis were considered. Projected velocity distributions were calculated from the high-speed experimental sequences using two methods: a physics-based optical flow algorithm and tracking of radio-opaque particles. Particle trajectories were also used to evaluate accumulated shear stress. Results were then compared with computational fluid dynamics (CFD) simulations to confirm the results of the high-speed imaging method. Flow patterns derived from HSA coincided with the impingement regions and recirculation zones formed in the aortic root as seen in the CFD for both graft configurations. Compared with the 45° graft, the 90° configuration resulted in 81% higher two-dimensional-projected velocities (over 100 cm/s) along the contralateral wall of the aorta. Both graft configurations suggest elevated accumulated shear stresses along individual trajectories. Compared with CFD simulations, HSA successfully characterized the fast-moving flow and hemodynamics in each LVAD graft configuration in vitro , demonstrating the potential utility of this technology as a quantitative imaging modality. Competing Interests: Disclosure: The authors have no conflicts of interest to report. (Copyright © ASAIO 2023.)
Databáze:	MEDLINE
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