Brain iron content in cerebral amyloid angiopathy using quantitative susceptibility mapping.

Autor:	Sharma B; Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada., Beaudin AE; Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada., Cox E; Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada., Saad F; Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.; Seaman Family MR Research Centre, University of Calgary, Calgary, AB, Canada., Nelles K; Department of Medicine (Neurology), University of Alberta, Edmonton, AB, Canada., Gee M; Department of Medicine (Neurology), University of Alberta, Edmonton, AB, Canada., Frayne R; Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.; Seaman Family MR Research Centre, University of Calgary, Calgary, AB, Canada.; Department of Radiology, University of Calgary, Calgary, AB, Canada.; Calgary Image Processing and Analysis Centre, University of Calgary, Calgary, AB, Canada., Gobbi DG; Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.; Department of Radiology, University of Calgary, Calgary, AB, Canada.; Calgary Image Processing and Analysis Centre, University of Calgary, Calgary, AB, Canada., Camicioli R; Department of Medicine (Neurology), University of Alberta, Edmonton, AB, Canada.; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada., Smith EE; Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.; Seaman Family MR Research Centre, University of Calgary, Calgary, AB, Canada., McCreary CR; Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.; Seaman Family MR Research Centre, University of Calgary, Calgary, AB, Canada.; Department of Radiology, University of Calgary, Calgary, AB, Canada.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroscience [Front Neurosci] 2023 Apr 17; Vol. 17, pp. 1139988. Date of Electronic Publication: 2023 Apr 17 (Print Publication: 2023).
DOI:	10.3389/fnins.2023.1139988
Abstrakt:	Introduction: Cerebral amyloid angiopathy (CAA) is a small vessel disease that causes covert and symptomatic brain hemorrhaging. We hypothesized that persons with CAA would have increased brain iron content detectable by quantitative susceptibility mapping (QSM) on magnetic resonance imaging (MRI), and that higher iron content would be associated with worse cognition. Methods: Participants with CAA ( n = 21), mild Alzheimer's disease with dementia (AD-dementia; n = 14), and normal controls (NC; n = 83) underwent 3T MRI. Post-processing QSM techniques were applied to obtain susceptibility values for regions of the frontal and occipital lobe, thalamus, caudate, putamen, pallidum, and hippocampus. Linear regression was used to examine differences between groups, and associations with global cognition, controlling for multiple comparisons using the false discovery rate method. Results: No differences were found between regions of interest in CAA compared to NC. In AD, the calcarine sulcus had greater iron than NC (β = 0.99 [95% CI: 0.44, 1.53], q < 0.01). However, calcarine sulcus iron content was not associated with global cognition, measured by the Montreal Cognitive Assessment ( p > 0.05 for all participants, NC, CAA, and AD). Discussion: After correcting for multiple comparisons, brain iron content, measured via QSM, was not elevated in CAA compared to NC in this exploratory study. Competing Interests: ES reports consulting for Eli Lilly. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Sharma, Beaudin, Cox, Saad, Nelles, Gee, Frayne, Gobbi, Camicioli, Smith and McCreary.)
Databáze:	MEDLINE
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