Growing old together: What we know about the influence of diet and exercise on the aging host's gut microbiome.

Autor:	Brooks CN; Department of Biology, Appalachian State University, Boone, NC, United States., Wight ME; Department of Biology, Appalachian State University, Boone, NC, United States., Azeez OE; Department of Biology, Appalachian State University, Boone, NC, United States., Bleich RM; Department of Biology, Appalachian State University, Boone, NC, United States., Zwetsloot KA; Department of Biology, Appalachian State University, Boone, NC, United States.; Department of Public Health and Exercise Science, Appalachian State University, Boone, NC, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in sports and active living [Front Sports Act Living] 2023 Apr 17; Vol. 5, pp. 1168731. Date of Electronic Publication: 2023 Apr 17 (Print Publication: 2023).
DOI:	10.3389/fspor.2023.1168731
Abstrakt:	The immune system is critical in defending against infection from pathogenic microorganisms. Individuals with weakened immune systems, such as the elderly, are more susceptible to infections and developing autoimmune and inflammatory diseases. The gut microbiome contains a plethora of bacteria and other microorganisms, which collectively plays a significant role in immune function and homeostasis. Gut microbiota are considered to be highly influential on host health and immune function. Therefore, dysbiosis of the microbiota could be a major contributor to the elevated incidence of multiple age-related pathologies. While there seems to be a general consensus that the composition of gut microbiota changes with age, very little is known about how diet and exercise might influence the aging microbiome. Here, we examine the current state of the literature regarding alterations to the gut microbiome as hosts age, drawing particular attention to the knowledge gaps in addressing how diet and exercise influence the aging microbiome. Further, we will demonstrate the need for more controlled studies to investigate the roles that diet and exercise play driving the composition, diversity, and function of the microbiome in an aging population. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2023 Brooks, Wight, Azeez, Bleich and Zwetsloot.)
Databáze:	MEDLINE
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