Immune phenotype is differentially affected by changing the type of bovine respiratory disease vaccine administered at revaccination in beef heifers.

Autor:	Reddout C; Department of Animal and Food Sciences, Oklahoma State University, Stillwater, OK, United States., Hernandez LP; Department of Animal and Food Sciences, Oklahoma State University, Stillwater, OK, United States., Chase CCL; Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD, United States., Beck P; Department of Animal and Food Sciences, Oklahoma State University, Stillwater, OK, United States., White F; Elanco Animal Health, Greenfield, IN, United States., Salak-Johnson JL; Department of Animal and Food Sciences, Oklahoma State University, Stillwater, OK, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in veterinary science [Front Vet Sci] 2023 Apr 17; Vol. 10, pp. 1161902. Date of Electronic Publication: 2023 Apr 17 (Print Publication: 2023).
DOI:	10.3389/fvets.2023.1161902
Abstrakt:	During preconditioning, modified-live vaccines are frequently administered to beef calves before weaning. In this study, we began to characterize the immune phenotype of calves that received a modified-live vaccination at 3-4 months of age and then either received the same modified-live or an inactivated vaccine upon arrival at the feedlot (weaning) and 28 days post-arrival (booster). Innate and adaptive immune measures were assessed before revaccination and 14 and 28 days post. Heifers that received three doses of the modified-live vaccine exhibited a relatively balanced immune response based on increases in mean cytokine concentrations (IL-17, IL-21) and total immunoglobulin-G (IgG) and subsets IgG1 and IgG2, which are related to both arms of the adaptive immune system. Conversely, heifers that received one dose of modified live and two doses of the inactivated vaccine had a more robust neutrophil chemotactic response and greater serum-neutralizing antibody titers, resulting in an enhanced innate immune and a skewed proinflammatory response. These results indicate that the revaccination protocol used after initial vaccination with a modified-live vaccine differentially influences the immune phenotype of beef calves, with three doses of modified live inducing potentially immune homeostasis and a combination of modified live and inactivated vaccines inducing a skewed immune phenotype. However, more research is needed to determine the protective efficacy of these vaccination protocols against disease. Competing Interests: FW is an employee by Elanco Animal Health. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Reddout, Hernandez, Chase, Beck, White and Salak-Johnson.)
Databáze:	MEDLINE
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