C-reactive protein and D-dimer in cerebral vein thrombosis: Relation to clinical and imaging characteristics as well as outcomes in a French cohort study.
| Autor: | Billoir P; Univ Rouen Normandie, INSERM U1096, Department of Vascular Hemostasis Unit, CHU Rouen, Rouen, France., Siguret V; Department of Biological Hematology, Lariboisière University Hospital, Université Paris Cité, Paris, France., Fron EM; Department of Biological Hematology, Lariboisière University Hospital, Université Paris Cité, Paris, France., Drouet L; Department of Biological Hematology, Lariboisière University Hospital, Université Paris Cité, Paris, France., Crassard I; Department of Neurology, Lariboisière University Hospital, Université Paris Cité, Paris, France., Marlu R; Department of Biological Hematology, Grenoble University Hospital, Grenoble, France., Barbieux-Guillot M; Department of Neurology, Grenoble University Hospital, Grenoble, France., Morange PE; Department of Biological Hematology, Marseille University Hospital, Marseille, France., Robinet E; Department of Neurology, Marseille University Hospital, Marseille, France., Metzger C; Department of Biological Hematology, Strasbourg University Hospital, Strasbourg, France., Wolff V; Department of Neurology, Strasbourg University Hospital, Strasbourg, France., André-Kerneis E; Department of Biological Hematology, Meaux Hospital, Meaux, France., Klapczynski F; Department of Neurology, Meaux Hospital, Meaux, France., Martin-Bastenaire B; Department of Biological Hematology, Versailles Hospital, Versailles, France., Pico F; Department of Neurology, Versailles Hospital, Versailles, France., Menard F; Department of Biological Hematology, Bayonne Hospital, Bayonne, France., Ellie E; Department of Neurology, Bayonne Hospital, Bayonne, France., Freyburger G; Department of Biological Hematology, Bordeaux University Hospital, Bordeaux, France., Rouanet F; Department of Neurology, Bordeaux University Hospital, Bordeaux, France., Allano HA; Department of Biological Hematology, La Rochelle Hospital, La Rochelle, France., Godenèche G; Department of Neurology, La Rochelle Hospital, La Rochelle, France., Mourey G; Department of Biological Hematology, Besançon University Hospital, Besançon, France., Moulin T; Department of Neurology, Besançon University Hospital, Besançon, France., Berruyer M; Department of Biological Hematology, Lyon University Hospital, Lyon, France., Derex L; Department of Neurology, Lyon University Hospital, Lyon, France., Trichet C; Department of Biological Hematology, Argenteuil Hospital, Argenteuil, France., Runavot G; Department of Neurology, Argenteuil Hospital, Argenteuil, France., Le Querrec A; Department of Biological Hematology, Caen University Hospital, Caen, France., Viader F; Department of Neurology, Caen University Hospital, Caen, France., Cluet-Dennetiere S; Department of Biological Hematology, Compiègne Hospital, Compiègne, France., Husein TT; Department of Neurology, Compiègne Hospital, Compiègne, France., Donnard M; Department of Biological Hematology, Limoges University Hospital, Limoges, France., Macian-Montoro F; Department of Neurology, Limoges University Hospital, Limoges, France., Ternisien C; Department of Biological Hematology, Nantes University Hospital, Nantes, France., Guillon B; Department of Neurology, Nantes University Hospital, Nantes, France., Laplanche S; Department of Biological Hematology, Saint Joseph Hospital, Paris, France., Zuber M; Department of Neurology, Saint Joseph Hospital, Paris, France., Peltier JY; Department of Biological Hematology, Poissy Hospital, Poissy, France., Tassan P; Department of Neurology, Poissy Hospital, Poissy, France., Roussel B; Department of Biological Hematology, Amiens university Hospital, Amiens, France., Canaple S; Department of Neurology, Amiens university Hospital, Amiens, France., Scavazza E; Department of Biological Hematology, Perpignan Hospital, Perpignan, France., Gaillard N; Department of Neurology, Perpignan Hospital, Perpignan, France., Triquenot Bagan A; Department of Neurology, CHU Rouen, Rouen, France., Le Cam Duchez V; Univ Rouen Normandie, INSERM U1096, Department of Vascular Hemostasis Unit, CHU Rouen, Rouen, France. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Research and practice in thrombosis and haemostasis [Res Pract Thromb Haemost] 2023 Mar 28; Vol. 7 (3), pp. 100130. Date of Electronic Publication: 2023 Mar 28 (Print Publication: 2023). |
| DOI: | 10.1016/j.rpth.2023.100130 |
| Abstrakt: | Introduction: Cerebral venous sinus thrombosis (CVST) is a rare disease with highly variable clinical presentation and outcomes. Clinical studies suggest a role of inflammation and coagulation in CVST outcomes. The aim of this study was to investigate the association of inflammation and hypercoagulability biomarkers with CVST clinical manifestations and prognosis. Methods: This prospective multicenter study was conducted from July 2011 to September 2016. Consecutive patients referred to 21 French stroke units and who had a diagnosis of symptomatic CVST were included. High-sensitivity C-reactive protein (hs-CRP), neutrophil-to-lymphocyte ratio (NLR), D-dimer, and thrombin generation using calibrated automated thrombogram system were measured at different time points until 1 month after anticoagulant therapy discontinuation. Results: Two hundred thirty-one patients were included. Eight patients died, of whom 5 during hospitalization. The day 0 hs-CRP levels, NLR, and D-dimer were higher in patients with initial consciousness disturbance than in those without (hs-CRP: 10.2 mg/L [3.6-25.5] vs 23.7 mg/L [4.8-60.0], respectively; NLR: 3.51 [2.15-5.88] vs 4.78 [3.10-9.59], respectively; D-dimer: 950 μg/L [520-2075] vs 1220 μg/L [950-2445], respectively). Patients with ischemic parenchymal lesions (n = 31) had a higher endogenous thrombin potential Conclusion: Two widely available biomarkers measured upon admission, especially hs-CRP, could help predict bad prognosis in CVST in addition to patient characteristics. These results need to be validated in other cohorts. (© 2023 The Authors.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|
Plný text