Application of multi-spectral CT imaging in Crohn's disease: a systematic review.
| Autor: | Grassi G; Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), Cagliari, Italy., Laino ME; Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), Cagliari, Italy.; Artificial Intelligence Center, IRCSS Humanitas Research Hospital, Rozzano, Milano, Italy., Kalra M; Department of Radiology, Massachusetts General Hospital and the Harvard Medical School, Boston, MA, USA., Cherchi MV; Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), Cagliari, Italy., Nicola R; Department of Radiology, Roswell Park Cancer Institute, Jacobs School of Medicine and Biomedical Science, Buffalo, NY, USA., Mannelli L; Department of Radiology, IRCCS SDN, Naples, Italy., Balestrieri A; Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), Cagliari, Italy., Suri JS; Diagnostic and Monitoring Division, AtheroPoint™, Roseville, CA, USA.; Knowledge Engineering Center, Global Biomedical Technologies, Inc., Roseville, CA, USA.; Department of Electrical and Computer Engineering, Idaho State University, Pocatello, ID, USA (Affl)., Sala E; Department of Radiology, University of Cambridge, Cambridge, UK., Saba L; Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), Cagliari, Italy. |
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| Jazyk: | angličtina |
| Zdroj: | Acta radiologica (Stockholm, Sweden : 1987) [Acta Radiol] 2023 Aug; Vol. 64 (8), pp. 2347-2356. Date of Electronic Publication: 2023 May 03. |
| DOI: | 10.1177/02841851231170849 |
| Abstrakt: | Background: No quantitative computed tomography (CT) biomarker is actually sufficiently accurate to assess Crohn's disease (CD) lesion activity, with adequate precision to guide clinical decisions. Purpose: To assess the available literature on the use of iodine concentration (IC), from multi-spectral CT acquisition, as a quantitative parameter able to distinguish healthy from affected bowel and assess CD bowel activity and heterogeneity of activity along the involved segments. Material and Methods: A literature search was conducted to identify original research studies published up to February 2022. The inclusion criteria were original research papers (>10 human participants), English language publications, focus on dual-energy CT (DECT) of CD with iodine quantification (IQ) as an outcome measure. The exclusion criteria were animal-only studies, languages other than English, review articles, case reports, correspondence, and study populations <10 patients. Results: Nine studies were included in this review; all of which showed a strong correlation between IC measurements and CD activity markers, such as CD activity index (CDAI), endoscopy findings and simple endoscopic score for Crohn's disease (SES-CD), and routine CT enterography (CTE) signs and histopathologic score. Statistically significant differences in IC were reported between affected bowel segments and healthy ones (higher P value was P < 0.001), normal segments and those with active inflammation ( P < 0.0001) as well as between patients with active disease and those in remission ( P < 0.001). Conclusion: The mean normalized IC at DECTE could be a reliable tool in assisting radiologists in the diagnosis, classification and grading of CD activity. |
| Databáze: | MEDLINE |
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