Selection-driven trait loss in independently evolved cavefish populations.

Autor: Moran RL; Department of Ecology, Evolution, and Behavior, University of Minnesota, Saint Paul, MN, USA. rlmoran@tamu.edu.; Department of Biology, Texas A&M University, College Station, TX, USA. rlmoran@tamu.edu., Richards EJ; Department of Ecology, Evolution, and Behavior, University of Minnesota, Saint Paul, MN, USA., Ornelas-García CP; Colección Nacional de Peces, Departamento de Zoología, Instituto de Biología, Universidad Nacional Autónoma de México, Tercer Circuito Exterior S/N. CP 04510, D. F. México, México City, México., Gross JB; Department of Biological Sciences, University of Cincinnati, Cincinnati, OH, USA., Donny A; Department of Ecology, Evolution, and Behavior, University of Minnesota, Saint Paul, MN, USA., Wiese J; Department of Ecology, Evolution, and Behavior, University of Minnesota, Saint Paul, MN, USA., Keene AC; Department of Biology, Texas A&M University, College Station, TX, USA., Kowalko JE; Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA., Rohner N; Stowers Institute for Medical Research, Kansas City, MO, USA.; Department of Molecular & Integrative Physiology, KU Medical Center, Kansas City, KS, USA., McGaugh SE; Department of Ecology, Evolution, and Behavior, University of Minnesota, Saint Paul, MN, USA.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 May 03; Vol. 14 (1), pp. 2557. Date of Electronic Publication: 2023 May 03.
DOI: 10.1038/s41467-023-37909-8
Abstrakt: Laboratory studies have demonstrated that a single phenotype can be produced by many different genotypes; however, in natural systems, it is frequently found that phenotypic convergence is due to parallel genetic changes. This suggests a substantial role for constraint and determinism in evolution and indicates that certain mutations are more likely to contribute to phenotypic evolution. Here we use whole genome resequencing in the Mexican tetra, Astyanax mexicanus, to investigate how selection has shaped the repeated evolution of both trait loss and enhancement across independent cavefish lineages. We show that selection on standing genetic variation and de novo mutations both contribute substantially to repeated adaptation. Our findings provide empirical support for the hypothesis that genes with larger mutational targets are more likely to be the substrate of repeated evolution and indicate that features of the cave environment may impact the rate at which mutations occur.
(© 2023. The Author(s).)
Databáze: MEDLINE
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