Parabolic avalanche scaling in the synchronization of cortical cell assemblies.

Autor: Capek E; Section on Critical Brain Dynamics, National Institute of Mental Health, Bethesda, MD, USA., Ribeiro TL; Section on Critical Brain Dynamics, National Institute of Mental Health, Bethesda, MD, USA., Kells P; Section on Critical Brain Dynamics, National Institute of Mental Health, Bethesda, MD, USA., Srinivasan K; Section on Critical Brain Dynamics, National Institute of Mental Health, Bethesda, MD, USA.; Department of Physics, University of Maryland, College Park, MD, USA., Miller SR; Section on Critical Brain Dynamics, National Institute of Mental Health, Bethesda, MD, USA., Geist E; Section on Critical Brain Dynamics, National Institute of Mental Health, Bethesda, MD, USA., Victor M; Section on Critical Brain Dynamics, National Institute of Mental Health, Bethesda, MD, USA., Vakili A; Section on Critical Brain Dynamics, National Institute of Mental Health, Bethesda, MD, USA., Pajevic S; Section on Critical Brain Dynamics, National Institute of Mental Health, Bethesda, MD, USA., Chialvo DR; CEMSC3, Escuela de Ciencia y Tecnologia, UNSAM, San Martín, P. Buenos Aires, Argentina., Plenz D; Section on Critical Brain Dynamics, National Institute of Mental Health, Bethesda, MD, USA. plenzd@mail.nih.gov.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 May 03; Vol. 14 (1), pp. 2555. Date of Electronic Publication: 2023 May 03.
DOI: 10.1038/s41467-023-37976-x
Abstrakt: Neurons in the cerebral cortex fire coincident action potentials during ongoing activity and in response to sensory inputs. These synchronized cell assemblies are fundamental to cortex function, yet basic dynamical aspects of their size and duration are largely unknown. Using 2-photon imaging of neurons in the superficial cortex of awake mice, we show that synchronized cell assemblies organize as scale-invariant avalanches that quadratically grow with duration. The quadratic avalanche scaling was only found for correlated neurons, required temporal coarse-graining to compensate for spatial subsampling of the imaged cortex, and suggested cortical dynamics to be critical as demonstrated in simulations of balanced E/I-networks. The corresponding time course of an inverted parabola with exponent of χ = 2 described cortical avalanches of coincident firing for up to 5 s duration over an area of 1 mm 2 . These parabolic avalanches maximized temporal complexity in the ongoing activity of prefrontal and somatosensory cortex and in visual responses of primary visual cortex. Our results identify a scale-invariant temporal order in the synchronization of highly diverse cortical cell assemblies in the form of parabolic avalanches.
(© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
Databáze: MEDLINE
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