The secret life of lactate: A novel cell-cycle regulatory mechanism.
| Autor: | Cluntun AA; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Rutter J; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA; Howard Hughes Medical Institute, Salt Lake City, UT, USA. Electronic address: rutter@biochem.utah.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Cell metabolism [Cell Metab] 2023 May 02; Vol. 35 (5), pp. 730-732. |
| DOI: | 10.1016/j.cmet.2023.04.006 |
| Abstrakt: | Recently, Liu et al. uncovered an unexpected L-lactate-Zn 2+ interaction in the active site of the deSUMOylating enzyme SENP1 that triggers a sequence of events that lead to mitotic exit. This study opens the door to new research avenues of metabolite-metal interactions controlling cellular decisions and functions. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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