Oculosystemic pneumocystosis in 2 sibling Chihuahuas.

Autor: Johnson LR; Department of Medicine and Epidemiology, University of California-Davis, Davis, California, USA., Hulsebosch SE; Department of Medicine and Epidemiology, University of California-Davis, Davis, California, USA., Viall AK; Department of Pathology, Microbiology & Immunology, University of California-Davis, Davis, California, USA., Danesi P; Parasitology, Mycology and Medical Enthomology, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy., Woolard KD; Department of Pathology, Microbiology & Immunology, University of California-Davis, Davis, California, USA., Cook SE; Comparative Pathology Laboratory, University of California-Davis, Davis, California, USA., Maggs DJ; Department of Surgical and Radiological Sciences, University of California-Davis, Davis, California, USA., Leonard BC; Department of Surgical and Radiological Sciences, University of California-Davis, Davis, California, USA.
Jazyk: angličtina
Zdroj: Journal of veterinary internal medicine [J Vet Intern Med] 2023 May-Jun; Vol. 37 (3), pp. 1179-1185. Date of Electronic Publication: 2023 May 03.
DOI: 10.1111/jvim.16729
Abstrakt: Sibling female and male Chihuahuas were evaluated for a 9-month history of tachypnea that failed to respond to fenbendazole, doxycycline, amoxicillin-clavulanate, and prednisone. Physical examination identified tachypnea, hyperpnea, and harsh bronchovesicular lung sounds. Fundic examination disclosed diffuse chorioretinitis, manifested as multifocal chorioretinal granulomas in the female dog and occasional chorioretinal scars in the male dog. Thoracic radiographs indicated moderate to severe interstitial to broncho-interstitial infiltrates in both dogs. Serum and urine antigen and antibody testing in the female dog failed to identify infectious agents, but cytologic assessment of hepatic lymph node, liver, and splenic aspirates identified Pneumocystis trophozoites. Infection was confirmed in both dogs by 28S rRNA PCR sequencing from multiple tissue samples. The female dog responded well to trimethoprim-sulfamethoxazole, but the male dog was euthanized because of liver failure, presumably related to antimicrobial treatment.
(© 2023 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.)
Databáze: MEDLINE
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