Flexible Antagonist versus Agonist Flare Protocol in Women above 40 Undergoing IVF, A retrospective Cohort Study.

Autor:	Hassabelnabi EAF; Almana General Hospital, IVF unit, Eastern Provence, Saudi Arabia.; Department of Obstetrics and Gynecology, Faculty of medicine, Al-Azhar University, Cairo, Egypt., Badreldin MA; Almana General Hospital, IVF unit, Eastern Provence, Saudi Arabia., Behery MA; Assisted Reproduction Unit, The International Islamic Center for Population Studies and Research, Al-Azhar University, Cairo, Egypt., Rageh KA; Department of Obstetrics and Gynecology, Faculty of medicine, Al-Azhar University, Cairo, Egypt., Ali EA; Assisted Reproduction Unit, The International Islamic Center for Population Studies and Research, Al-Azhar University, Cairo, Egypt.
Jazyk:	angličtina
Zdroj:	JBRA assisted reproduction [JBRA Assist Reprod] 2023 Sep 12; Vol. 27 (3), pp. 381-385. Date of Electronic Publication: 2023 Sep 12.
DOI:	10.5935/1518-0557.20220064
Abstrakt:	Objective: Several strategies have been proposed for ovarian stimulation in older women, such as using an increased daily dose of gonadotropins (300-450 IU per day) with GnRH agonist (long or micro dose flare protocols), or using GnRH antagonist protocols. The objective of this study is to compare the efficacy of flexible GnRH antagonist protocol and GnRH agonist flare - pituitary block protocols for ovarian stimulation in women above 40 years old undergoing IVF. Methods: This study was performed between January 2016 and February 2019. One hundred and fourteen women aged between 40 and 42 years who underwent IVF were divided into two groups; group I were treated by Flexible GnRH antagonist protocol (Antagonist group, n=68); and group II were treated by Flare GnRH agonist protocol (Flare group, n=46). Results: Patients treated with the antagonist protocol had a significantly lower cancellation rate when compared with patients treated with flare agonist protocol (10.3% vs. 21.7%, p value 0.049). The other parameters evaluated did not show statistically significant differences. Conclusions: Our finding showed that both Flexible antagonist and Flare agonist protocols had comparable outcomes, with lower cycle cancellation rates for older patients treated with the antagonist protocol.
Databáze:	MEDLINE
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