Neonatal osteoblastic tumor with a novel PTBP1::FOSB fusion.

Autor: Blackburn PR; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Douglass DP; Department of Pediatrics, Hematology/Oncology Section, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Ramakrishnaiah RH; Department of Pediatric Radiology, Arkansas Children's Hospital, Little Rock, Arkansas, USA., Montgomery CO; Department of Orthopedics, Arkansas Children's Hospital, Little Rock, Arkansas, USA., Shi Z; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Wheeler DA; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Koo SC; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Jazyk: angličtina
Zdroj: Genes, chromosomes & cancer [Genes Chromosomes Cancer] 2023 Oct; Vol. 62 (10), pp. 611-616. Date of Electronic Publication: 2023 May 03.
DOI: 10.1002/gcc.23149
Abstrakt: Congenital/neonatal bone neoplasms are extremely rare. We present the case of a patient with a neonatal bone tumor of the fibula that had osteoblastic differentiation and a novel PTBP1::FOSB fusion. FOSB fusions are described in several different tumor types, including osteoid osteoma and osteoblastoma; however, these tumors typically present in the second or third decade of life, with case reports as young as 4 months of age. Our case expands the spectrum of congenital/neonatal bone lesions. The initial radiologic, histologic, and molecular findings supported the decision for close clinical follow-up rather than more aggressive intervention. Since the time of diagnosis, this tumor has undergone radiologic regression without treatment.
(© 2023 Wiley Periodicals LLC.)
Databáze: MEDLINE
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