Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study Protocol.

Autor: Crowley JJ; University of North Carolina at Chapel Hill, Department of Genetics, Chapel Hill, North Carolina, United States of America.; University of North Carolina at Chapel Hill, Department of Psychiatry, Chapel Hill, North Carolina, United States of America., Cappi C; Icahn School of Medicine at Mount Sinai, Department of Psychiatry, New York City, New York, United States of America.; Universidade de São Paulo, Departamento de Psiquiatria, São Paulo, São Paulo, Brasil., Ochoa-Panaifo ME; Universidad Privada del Norte, Lima, Lima, Perú., Frederick RM; Baylor College of Medicine, Department of Psychiatry and Behavioral Sciences, Houston, Texas, United States of America., Kook M; Baylor College of Medicine, Department of Psychiatry and Behavioral Sciences, Houston, Texas, United States of America., Wiese AD; Baylor College of Medicine, Department of Psychiatry and Behavioral Sciences, Houston, Texas, United States of America., Rancourt D; University of South Florida, Department of Psychology, Tampa, Florida, United States of America., Atkinson EG; Baylor College of Medicine, Department of Molecular and Human Genetics, Houston, Texas, United States of America., Giusti-Rodriguez P; University of Florida College of Medicine, Department of Psychiatry, Gainesville, Florida, United States of America., Anderberg JL; Baylor College of Medicine, Department of Psychiatry and Behavioral Sciences, Houston, Texas, United States of America., Abramowitz JS; University of North Carolina at Chapel Hill, Department of Psychology and Neuroscience, Chapel Hill, North Carolina, United States of America., Adorno VR; Hospital Psiquiátrico de Asunción, Direccion General, Asunción, Central, Paraguay., Aguirre C; Hospital Psiquiátrico de Asunción, Departamento de Psiquiatría, Asunción, Central, Paraguay., Alves GS; Universidade Federal da Bahia, Hospital Universitário Professor Edgard Santos, Serviço de Psiquiatria, Laboratório de Neuropsicofarmacologia - LANP, Salvador, Bahia, Brasil.; Universidade Federal da Bahia, Pós-Graduação em Medicina e Saúde, Faculdade de Medicina da Bahia, Salvador, Bahia, Brasil., Alves GS; Hospital Nina Rodrigues/Universidade Federal do Maranhão (UFMA), Sao Luis do Maranhão, Maranhão, Brasil., Ancalade N; University of North Carolina at Chapel Hill, Department of Genetics, Chapel Hill, North Carolina, United States of America., Espinosa AAA; Talk TOC, Cuidad de México, Ciudad de México, México., Arnold PD; University of Calgary, The Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Calgary, Alberta, Canada., Ayton DM; Baylor College of Medicine, Department of Psychiatry and Behavioral Sciences, Houston, Texas, United States of America., Barbosa IG; Universidade Federal de Minas Gerais, Departamento de Saúde Mental da Faculdade de Medicina, Belo Horizonte, Minas Gerais, Brasil., Castano LMB; Hospital Psiquiátrico Universitario Del Valle, Cali, Valle del Cauca, Colombia., Barrera CN; Centro TOC México, Ciudad de México, Ciudad de México, México., Prieto MB; Centro Interdisciplinario de Tourette, TOC, TDAH y Trastornos Asociados (CITA), Buenos Aires, Buenos Aires, Argentina., Berardo MC; Centro Interdisciplinario de Tourette, TOC, TDAH y Trastornos Asociados (CITA), Buenos Aires, Buenos Aires, Argentina., Berrones D; Rice University, Department of Psychology, Houston, Texas, United States of America., Best JR; University of British Columbia, Department of Psychiatry, Vancouver, British Columbia, Canada., Bigdeli TB; SUNY Downstate Health Sciences University, Department of Psychiatry and Behavioral Sciences, Brooklyn, New York, United States of America.; VA New York Harbor Healthcare System, Brooklyn, New York, United States of America., Burton CL; Hospital for Sick Children, Department of Neurosciences and Mental Health, Toronto, Ontario, Canada., Callahan JL; University of North Texas, Department of Psychology, Denton, Texas, United States of America., Carneiro MCB; Universidade Federal do Paraná, Departamento de Psiquiatria e Medicina Legal, Curitiba, Paraná, Brasil., Cepeda SL; University of Miami, Department of Psychology, Coral Gables, Florida, United States of America., Chazelle E; Centro Interdisciplinario de Tourette, TOC, TDAH y Trastornos Asociados (CITA), Buenos Aires, Buenos Aires, Argentina., Chire JM; Instituto Nacional de Salud Mental ''Honorio Delgado-Hideyo Noguchi'', Dirección de Niños y Adolescentes, Lima, Lima, Perú., Munoz MC; Universidad de Valparaíso, Instituto de Fisiología, Valparaíso, Valparaíso, Chile., Quiroz PC; Universidad Intercontinental, Ciudad de México, Ciudad de México, México., Cobite J; University of Houston, Department of Counseling Psychology, Houston, Texas, United States of America., Comer JS; Florida International University, Department of Psychology, Miami, Florida, United States of America., Costa DL; Universidade de São Paulo, Departamento de Psiquiatria, São Paulo, São Paulo, Brasil., Crosbie J; Hospital for Sick Children, Department of Neurosciences and Mental Health, Toronto, Ontario, Canada.; University of Toronto, Department of Psychiatry, Toronto, Ontario, Canada., Cruz VO; Instituto Nacional de Salud Mental ''Honorio Delgado-Hideyo Noguchi'', Oficina Ejecutiva de Investigación, Lima, Lima, Perú.; Universidad San Martin de Porres, School of Medicine, Lima, Lima, Perú., Dager G; Corporación Universitaria Rafael Nuñez, Cartagena, Bolivar, Colombia., Daza LF; Hospital Psiquiátrico Universitario Del Valle, Cali, Valle del Cauca, Colombia., de la Rosa-Gómez A; Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Iztacala, Tlalnepantla de Baz, Ciudad de México, México., Del Río D; UTOC, Ciudad de México, Ciudad de México, México., Delage FZ; Universidade Federal do Paraná, Departamento de Medicina Forense e Psiquiatria, Curitiba, Paraná, Brasil., Dreher CB; Universidade Federal do Rio Grande do Sul, Departamento de Psiquiatria, Porto Alegre, Rio Grande do Sul, Brasil.; Universidade Federal de Ciências da Saúde de Porto Alegre, Departamento de Psiquiatria - Clínica Médica, Porto Alegre, Rio Grande do Sul, Brasil., Fay L; Centro Interdisciplinario de Tourette, TOC, TDAH y Trastornos Asociados (CITA), Buenos Aires, Buenos Aires, Argentina., Fazio T; Centro Interdisciplinario de Tourette, TOC, TDAH y Trastornos Asociados (CITA), Buenos Aires, Buenos Aires, Argentina., Ferrão YA; Universidade Federal do Paraná de Porto Alegre, Departamento de Psiquiatria, Porto Alegre, Rio Grande do Sul, Brasil., Ferreira GM; Universidade Federal do Paraná, Departamento de Medicina Forense e Psiquiatria, Curitiba, Paraná, Brasil.; Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Parana, Brasil., Figueroa EG; Instituto Nacional de Salud Mental ''Honorio Delgado-Hideyo Noguchi'', Departamento de Psiquiatría de Adultos, Lima, Lima, Perú., Fontenelle LF; Universidade Federal do Rio de Janeiro, Departamento de Psiquiatria e Medicina Legal, Rio de Janeiro, Rio de Janeiro, Brasil.; Instituto D'Or de Pesquisa e Ensino, Departamento de Psiquiatria, Rio de Janeiro, Rio de Janeiro, Brasil., Forero DA; Fundación Universitaria del Área Andina, Escuela de Salud y Ciencias del Deporte, Bogotá, Bogotá, Colombia., Fragoso DT; Universidade Federal do Paraná, Departamento de Medicina Forense e Psiquiatria, Curitiba, Paraná, Brasil., Gadad BS; Texas Tech University Health Sciences Center El Paso, Department of Psychiatry, El Paso, Texas, United States of America., Garrison SR; Rogers Behavioral Health, Oconomowoc, Wisconsin, United States of America., González A; SIN TOC, Guadalajara, Jalisco, México., Gonzalez LD; Centro Interdisciplinario de Tourette, TOC, TDAH y Trastornos Asociados (CITA), Buenos Aires, Buenos Aires, Argentina., González MA; Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Iztacala, Tlalnepantla de Baz, Ciudad de México, México., Gonzalez-Barrios P; Universidad de Puerto Rico, Departamento de Psiquiatría, San Juan, Puerto Rico, Los Estados Unidos.; Universidad de Puerto Rico Campus de Ciências Médicas, San Juan, Puerto Rico, Los Estados Unidos., Goodman W; Baylor College of Medicine, Department of Psychiatry and Behavioral Sciences, Houston, Texas, United States of America., Guintivano J; University of North Carolina at Chapel Hill, Department of Psychiatry, Chapel Hill, North Carolina, United States of America., Guttfreund DG; Private Practice, San Salvador, San Salvador, El Savlador., Guzick AG; Baylor College of Medicine, Department of Psychiatry and Behavioral Sciences, Houston, Texas, United States of America., Halvorsen MW; University of North Carolina at Chapel Hill, Department of Genetics, Chapel Hill, North Carolina, United States of America., Hovey JD; The University of Texas Rio Grande Valley, Department of Psychological Science, Edinburg, Texas, United States of America., Janssen-Aguilar R; Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez, Subdirección de Psiquiatría, Ciudad de México, Ciudad de México, México., Jensen M; Universidad de Valparaíso, Centro de Neurociencias, Valparaíso, Valparaíso, Chile., Reynolds AZJ; Baylor College of Medicine, Department of Psychiatry and Behavioral Sciences, Houston, Texas, United States of America., Lujambio JAJ; Talk TOC, Cuautitlán Izcalli, Ciudad de México, México., Khalfe N; Baylor College of Medicine, School of Medicine, Houston, Texas, United States of America., Knutsen MA; Augustana College, Department of Psychology, Rock Island, Illinois, United States of America.; Baylor College of Medicine, Department of Psychiatry and Behavioral Sciences, Houston, Texas, United States of America., Lack C; University of Central Oklahoma, Department of Psychology, Edmond, Oklahoma, United States of America., Lanzagorta N; Grupo Médico Carracci, Departamento de Investigación Clínica, Ciudad de México, Ciudad de México, México., Lima MO; Universidade de São Paulo, Departamento de Psiquiatria, São Paulo, São Paulo, Brasil., Longhurst MO; Texas Tech University Health Sciences Center El Paso, Department of Psychiatry, El Paso, Texas, United States of America., Martinez DAL; Universidad Privada del Norte, Lima, Lima, Perú., Luna ES; Instituto Nacional de Salud Mental ''Honorio Delgado-Hideyo Noguchi'', Oficina Ejecutiva de Investigación, Lima, Lima, Perú., Marques AH; National Institute of Mental Heatlh (NIMH), Bethesda, Maryland, United States of America., Martinez M; DFW OCD Treatment Specialists, Richardson, Texas, United States of America.; Specialists in OCD and Anxiety Recovery (SOAR), Richardson, Texas, United States of America., de Los Angeles Matos M; Centro Interdisciplinario de Tourette, TOC, TDAH y Trastornos Asociados (CITA), Buenos Aires, Buenos Aires, Argentina., Maye CE; Baylor College of Medicine, Department of Psychiatry and Behavioral Sciences, Houston, Texas, United States of America., McGuire JF; Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, Maryland, United States of America., Menezes G; Universidade Federal do Rio de Janeiro, Programa de Ansiedade, Obsessões e Compulsões, Rio de Janeiro, Rio de Janeiro, Brasil., Minaya C; Fordham University, Department of Psychology, New York City, New York, United States of America., Miño T; Universidad de Valparaíso, Centro de Neurociencias, Valparaíso, Valparaíso, Chile., Mithani SM; University of Texas Health Science Center at San Antonio, School of Nursing, San Antonio, Texas, United States of America., de Oca CM; México Sin Estres, Ciudad de México, Ciudad de México, México., Morales-Rivero A; Centro Médico ABC, Ciudad de México, Ciudad de México, México., Moreira-de-Oliveira ME; Universidade Federal do Rio de Janeiro, Programa de Ansiedade, Obsessões e Compulsões, Rio de Janeiro, Rio de Janeiro, Brasil., Morris OJ; Baylor College of Medicine, Department of Psychiatry and Behavioral Sciences, Houston, Texas, United States of America., Muñoz SI; Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Iztacala, Tlalnepantla de Baz, Ciudad de México, México., Naqqash Z; University of British Columbia, Department of Psychiatry, Vancouver, British Columbia, Canada., Bracho AAN; SIN TOC, Guadalajara, Jalisco, México., Bracho BEN; SIN TOC, Guadalajara, Jalisco, México., Rojas MCO; Hospital Psiquiátrico Universitario Del Valle, Cali, Valle del Cauca, Colombia., Castaman LAO; Universidad Privada del Norte, Lima, Lima, Perú., Ortega I; University of Calgary, The Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Calgary, Alberta, Canada., Patel DI; University of Texas Health Science Center at San Antonio, School of Nursing, San Antonio, Texas, United States of America., Patrick AK; Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, Maryland, United States of America., Mino MPY; Universidad San Francisco de Quito, Clínica de Salud Mental USFQ, Quito, Pichincha, Ecuador.; Universidad San Francisco de Quito, Quito, Pichincha, Ecuador., Orellana JLP; Universidad Tegnológica Privada de Santa Cruz (UTEPSA), Santa Cruz de la Sierra, Andres Ibañez, Bolivia., Stumpf BP; Universidade Federal de Minas Gerais, Departamento de Saúde Mental da Faculdade de Medicina, Belo Horizonte, Minas Gerais, Brasil., Peregrina T; México Sin Estres, Ciudad de México, Ciudad de México, México., Duarte TP; Centro TOC México, Ciudad de México, Ciudad de México, México., Piacsek KL; Rogers Behavioral Health, Oconomowoc, Wisconsin, United States of America., Placencia M; Universidad Nacional Mayor de San Marcos, Departamento Académico de Ciencias Dinámicas, Lima, Lima, Perú., Quarantini LC; Universidade Federal da Bahia, Departamento de Neurociências e Saúde Mental, Faculdade de Medicina da Bahia, Salvador, Bahia, Brasil.; Universidade Federal da Bahia, Hospital Universitário Professor Edgard Santos, Serviço de Psiquiatria, Laboratório de Neuropsicofarmacologia - LANP, Salvador, Bahia, Brasil., Quarantini-Alvim Y; Universidade Federal da Bahia, Hospital Universitário Professor Edgard Santos, Serviço de Psiquiatria, Laboratório de Neuropsicofarmacologia - LANP, Salvador, Bahia, Brasil.; Faculdade Santa Casa, Faculdade de Psicologia, Salvador, Bahia, Brasil., Ramos RT; Sunnybrook Health Sciences Centre, Department of Psychiatry, Toronto, Ontario, Canada.; University of Toronto, Department of Psychiatry, Toronto, Ontario, Canada., Ramos IC; Sunnybrook Health Sciences Centre, Department of Psychiatry, Toronto, Ontario, Canada.; Frederick Thompson Anxiety Disorders Centre, Department of Psychiatry, Toronto, Ontario, Canada., Ramos VR; Universidade de São Paulo, Departamento de Psiquiatria, São Paulo, São Paulo, Brasil., Ramsey KA; Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, Maryland, United States of America., Ray EV; University of North Carolina at Chapel Hill, Department of Genetics, Chapel Hill, North Carolina, United States of America., Richter MA; Sunnybrook Health Sciences Centre, Department of Psychiatry, Toronto, Ontario, Canada.; University of Toronto, Department of Psychiatry, Temerty Faculty of Medicine, Toronto, Ontario, Canada., Riemann BC; Rogers Behavioral Health, Oconomowoc, Wisconsin, United States of America., Rivas JC; Hospital Psiquiátrico Universitario Del Valle, Cali, Valle del Cauca, Colombia.; Universidad del Valle, Departamento de Psiquiatría, Cali, Valle del Cauca, Colombia.; Universidad ICESI, Departamento de Psiquiatria, Cali, Valle del Cauca, Colombia.; Fundación Valle del Lili, Departamento de Psiquiatria, Cali, Valle del Cauca, Colombia., Rosario MC; Departamento de Psiquiatria da Universidade Federal de São Paulo (UNIFESP), São Paulo, São Paulo, Brasil., Ruggero CJ; University of North Texas, Department of Psychology, Denton, Texas, United States of America., Ruiz-Chow AA; Centro Médico ABC, Ciudad de México, Ciudad de México, México., Ruiz-Velasco A; Texas Tech University Health Sciences Center El Paso, Department of Psychiatry, El Paso, Texas, United States of America., Sampaio AS; Universidade Federal da Bahia, Departamento de Neurociências e Saúde Mental, Faculdade de Medicina da Bahia, Salvador, Bahia, Brasil.; Universidade Federal da Bahia, Pós-Graduação em Medicina e Saúde, Faculdade de Medicina da Bahia, Salvador, Bahia, Brasil.; Universidade Federal da Bahia, Hospital Universitário Professor Edgard Santos, Serviço de Psiquiatria, Laboratório de Neuropsicofarmacologia - LANP, Salvador, Bahia, Brasil., Saraiva LC; Universidade de São Paulo, Departamento de Psiquiatria, São Paulo, São Paulo, Brasil., Schachar RJ; Hospital for Sick Children, Department of Neurosciences and Mental Health, Toronto, Ontario, Canada.; University of Toronto, Department of Psychiatry, Toronto, Ontario, Canada., Schneider SC; Baylor College of Medicine, Department of Psychiatry and Behavioral Sciences, Houston, Texas, United States of America., Schweissing EJ; Baylor College of Medicine, Department of Psychiatry and Behavioral Sciences, Houston, Texas, United States of America., Seligman LD; The University of Texas Rio Grande Valley, Department of Psychological Science, Edinburg, Texas, United States of America., Shavitt RG; Universidade de São Paulo, Departamento de Psiquiatria, São Paulo, São Paulo, Brasil., Soileau KJ; Baylor College of Medicine, Department of Psychiatry and Behavioral Sciences, Houston, Texas, United States of America., Stewart SE; University of British Columbia, Department of Psychiatry, Vancouver, British Columbia, Canada.; BC Mental Health and Substance Use Services, Vancouver, British Columbia, Canada.; BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada., Storch SB; Washington University in St. Louis, St. Louis, Missouri, United States of America., Strouphauer ER; Baylor College of Medicine, School of Medicine, Houston, Texas, United States of America., Timpano KR; University of Miami, Department of Psychology, Coral Gables, Florida, United States of America., Treviño-de la Garza B; Universidad de Monterrey, Departamento de Psicología, Monterrey, Nuevo León, México., Vargas-Medrano J; Texas Tech University Health Sciences Center El Paso, Department of Psychiatry, El Paso, Texas, United States of America., Vásquez MI; Hospital Nacional Arzobispo Loayza, Servicio de Salud Mental, Lima, Lima, Perú., Martinez GV; Texas Tech University Health Sciences Center El Paso, Department of Psychiatry, El Paso, Texas, United States of America., Weinzimmer SA; Baylor College of Medicine, Department of Psychiatry and Behavioral Sciences, Houston, Texas, United States of America., Yanez MA; Baylor College of Medicine, Department of Psychiatry and Behavioral Sciences, Houston, Texas, United States of America., Zai G; Centre for Addiction and Mental Health, Neurogenetics Section, Molecular Brain Sciences Department, Toronto, Ontario, Canada.; University of Toronto, Department of Psychiatry, Temerty Faculty of Medicine, Toronto, Ontario, Canada., Zapata-Restrepo LM; Fundación Valle del Lili, Departamento de Psiquiatria, Cali, Valle, Colombia.; Universidad ICESI, Facultad de Ciencias de la Salud, Cali, Valle, Colombia.; Global Brain Health Institute - University of California San Francisco, Department of Neurology, San Francisco, California, United States of America., Zappa LM; Centro Interdisciplinario de Tourette, TOC, TDAH y Trastornos Asociados (CITA), Buenos Aires, Buenos Aires, Argentina.; Hospital de Niños Ricardo Gutierrez, Departamento de Salud Mental, Buenos Aires, Buenos Aires, Argentina.; Hospital Universitario Austral, Materno Infantil, Buenos Aires, Buenos Aires, Argentina., Zepeda-Burgos RM; Universidad Dr. José Matías Delgado, Centro de Investigación en Ciencias y Humanidades, Santa Tecla, La Libertad, El Salvador., Zoghbi AW; Baylor College of Medicine, Department of Psychiatry and Behavioral Sciences, Houston, Texas, United States of America.; New York State Psychiatric Institute, Department of Psychiatry, New York City, New York, United States of America., Miguel EC; Universidade de São Paulo, Departamento de Psiquiatria, São Paulo, São Paulo, Brasil., Rodriguez CI; Stanford University School of Medicine, Department of Psychiatry and Behavioral Sciences, Stanford, California, United States of America.; Veterans Affairs Palo Alto Health Care System, Department of Psychiatry, Temerty Faculty of Medicine, Palo Alto, California, United States of America., Mallen MCM; Centro Médico ABC, Ciudad de México, Ciudad de México, México., Moya PR; Universidad de Valparaíso, Instituto de Fisiología, Valparaíso, Valparaíso, Chile.; Centro Interdisciplinario de Neurociencia de Valparaiso (CINV), Valparaíso, Valparaíso, Chile., Borda T; Instituto Realize, Buenos Aires, Buenos Aires, Argentina.; Universidad Catolica Argentina, Facultad de Psicologia, Buenos Aires, Buenos Aires, Argentina., Moyano MB; Centro Interdisciplinario de Tourette, TOC, TDAH y Trastornos Asociados (CITA), Buenos Aires, Buenos Aires, Argentina.; Asociacion de Psiquiatras Argentinos (APSA), Buenos Aires, Buenos Aires, Argentina.; Asociacion de Psiquiatras Argentinos (APSA), Presidente del Capitulo de Investigacion en Psiquiatria, Buenos Aires, Buenos Aires, Argentina., Mattheisen M; Dalhousie University, Department of Community Health and Epidemiology & Faculty of Computer Science, Halifax, Nova Scotia, Canada.; LMU Munich, Institute of Psychiatric Phenomics and Genomics (IPPG), Munich, Germany., Pereira S; Baylor College of Medicine, Center for Medical Ethics and Health Policy, Houston, Texas, United States of America., Lázaro-Muñoz G; Harvard University School of Medicine, Center for Bioethics, Boston, Massachusetts, United States of America.; Massachusetts General Hospital, Department of Psychiatry, Boston, Massachusetts, United States of America., Martinez-Gonzalez KG; Universidad de Puerto Rico, Departamento de Psiquiatría, San Juan, Puerto Rico, Los Estados Unidos., Pato MT; Rutgers University- Robert Wood Johnson Medical School, Department of Psychiatry, Piscataway, New Jersey, United States of America., Nicolini H; Grupo Médico Carracci, Departamento de Psiquiatría, Ciudad de México, Ciudad de México, México.; Instituto Nacional de Medicina Genómica, Laboratorio de Genómica de Enfermedades Psiquiátricas y Neurodegenerativas, Ciudad de México, Ciudad de México, México., Storch EA; Baylor College of Medicine, Department of Psychiatry and Behavioral Sciences, Houston, Texas, United States of America.
Jazyk: angličtina
Zdroj: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Feb 26. Date of Electronic Publication: 2023 Feb 26.
DOI: 10.1101/2023.02.23.23286373
Abstrakt: Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5,000 richly-phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.
Databáze: MEDLINE