SARS-CoV-2: Air pollution highly correlated to the increase in mortality. The case of Guadalajara, Jalisco, México.

Autor: Torres-Anguiano E; Onkogenetik/Mexicana de Investigación y Biotectogía S.A. de C.V, Guadalajara, Jalisco, Mexico.; Unidad de Biología Molecular, Investigación y Diagnóstico, Hospital San Javier, Guadalajara, Jalisco, Mexico., Sánchez-López I; Onkogenetik/Mexicana de Investigación y Biotectogía S.A. de C.V, Guadalajara, Jalisco, Mexico.; Unidad de Biología Molecular, Investigación y Diagnóstico, Hospital San Javier, Guadalajara, Jalisco, Mexico., Garduno-Robles A; Onkogenetik/Mexicana de Investigación y Biotectogía S.A. de C.V, Guadalajara, Jalisco, Mexico., Rivas-Carrillo JD; Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico., Rivera-León EA; Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico., Sánchez-Enríquez S; Departamento de Clínicas, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitlán de Morelos, Jalisco, Mexico., Ornelas-Hernández LF; Onkogenetik/Mexicana de Investigación y Biotectogía S.A. de C.V, Guadalajara, Jalisco, Mexico., Zazueta León-Quintero F; Onkogenetik/Mexicana de Investigación y Biotectogía S.A. de C.V, Guadalajara, Jalisco, Mexico.; Unidad de Biología Molecular, Investigación y Diagnóstico, Hospital San Javier, Guadalajara, Jalisco, Mexico., Salazar León-Quintero EN; Hospital Civil de Guadalajara 'Fray Antonio Alcalde', Guadalajara, Jalisco, Mexico., Juárez-López GE; Onkogenetik/Mexicana de Investigación y Biotectogía S.A. de C.V, Guadalajara, Jalisco, Mexico.; Unidad de Biología Molecular, Investigación y Diagnóstico, Hospital San Javier, Guadalajara, Jalisco, Mexico., Sánchez-Zubieta FA; Departamento de Clínicas Médicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.; Servicio de Hemato-Oncología Pediátrica, Hospital Civil de Guadalajara 'Dr. Juan I. Menchaca', Guadalajara, Jalisco, Mexico., Ochoa-Bru M; Onkogenetik/Mexicana de Investigación y Biotectogía S.A. de C.V, Guadalajara, Jalisco, Mexico.; Unidad de Biología Molecular, Investigación y Diagnóstico, Hospital San Javier, Guadalajara, Jalisco, Mexico., Zepeda-Moreno A; Onkogenetik/Mexicana de Investigación y Biotectogía S.A. de C.V, Guadalajara, Jalisco, Mexico.; Unidad de Biología Molecular, Investigación y Diagnóstico, Hospital San Javier, Guadalajara, Jalisco, Mexico.; Departamento de Clínicas Médicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
Jazyk: angličtina
Zdroj: Infectious Disease Modelling [Infect Dis Model] 2023 Jun; Vol. 8 (2), pp. 445-457. Date of Electronic Publication: 2023 Apr 20.
DOI: 10.1016/j.idm.2023.04.004
Abstrakt: Objectives: To determine whether air pollution or changes in SARS-CoV-2 lineages lead to an increase in mortality.
Methods: Descriptive statistics were used to calculate rates of infection (2020-2021). RT-PCR was used to compare viral loads from October 2020 to February 2021. Next-generation sequencing (NGS) (n = 92) was used to examine and phylogenetically map SARS-CoV-2 lineages. A correlative "air pollution/temperature" index (I) was developed using regression analysis. PM 2.5 , PM 10 , O 3 , NO 2 , SO 2 , and CO concentrations were analyzed and compared to the mortality.
Results: The mortality rate during the last year was ∼32%. Relative SARS-CoV-2 viral loads increased in December 2020 and January 2021. NGS revealed that approximately 80% of SARS-CoV-2 linages were B.1.243 (33.7%), B1.1.222 (11.2%), B.1.1 (9%), B.1 (7%), B.1.1.159 (7%), and B.1.2 (7%). Two periods were analyzed, the prehigh- and high-mortality periods and no significant lineage differences or new lineages were found. Positive correlations of air pollution/temperature index values with mortality were found for IPM 2.5 and IPM 10 . INO 2 . ISO 2 , and ICO but not for O 3 . Using ICO, we developed a model to predict mortality with an estimated variation of ∼±5 deaths per day.
Conclusion: The mortality rate in the MZG was highly correlated with air pollution indices and not with SARS-CoV-2 lineage.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2023 The Authors.)
Databáze: MEDLINE
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