| Autor: |
Meli VS; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA.; UCI Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC), University of California, Irvine, Irvine, CA 92697, USA., Veerasubramanian PK; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA.; UCI Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC), University of California, Irvine, Irvine, CA 92697, USA., Downing TL; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA.; UCI Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC), University of California, Irvine, Irvine, CA 92697, USA.; NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, CA 92697, USA.; Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697, USA., Wang W; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA., Liu WF; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA.; UCI Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC), University of California, Irvine, Irvine, CA 92697, USA.; Department of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA 92697, USA.; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697, USA.; Institute for Immunology, University of California, Irvine, Irvine, CA 92697, USA. |
| Abstrakt: |
Innate immune cells are responsible for eliminating foreign infectious agents and cellular debris, and their ability to perceive, respond to, and integrate biochemical and mechanical cues from their microenvironment eventually determines their behavior. In response to tissue injury, pathogen invasion, or a biomaterial implant, immune cells activate many pathways to initiate inflammation in the tissue. In addition to common inflammatory pathways, studies have demonstrated the role of the mechanosensitive proteins and transcriptional coactivators YAP and TAZ (YAP/TAZ) in inflammation and immunity. We review our knowledge of YAP/TAZ in controlling inflammation and immunity in innate immune cells. Furthermore, we discuss the roles of YAP/TAZ in inflammatory diseases, wound healing, and tissue regeneration and how they integrate mechanical cues with biochemical signaling during disease progression. Last, we comment on possible approaches that can be exploited to harness the therapeutic potential of YAP/TAZ in inflammatory diseases. |
